FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026108602> ?p ?o ?g. }

• W2026108602 endingPage "151" @default.
• W2026108602 startingPage "141" @default.
• W2026108602 abstract "Abstract Oncolytic virotherapy of tumors has shown promising results in both preclinical and clinical studies. Here, we investigated the therapeutic efficacy of a replication-competent vaccinia virus, GLV-1h68, against human pancreatic carcinomas in cell cultures and in nude mice. We found that GLV-1h68 was able to infect, replicate in, and lyse tumor cells in vitro. Virus-mediated marker gene expressions were readily detected. Moreover, s.c. PANC-1 pancreatic tumor xenografts were effectively treated by a single i.v. dose of GLV-1h68. Cancer killing was achieved with minimal toxicity. Viral titer analyses in homogenized organs and PANC-1 tumors showed that the mutant virus resides almost exclusively in the tumors and not in healthy organs. Except mild spleen enlargements, no histopathology changes were observed in any other organs 2 months after virus injection. Surprisingly, s.c. MIA PaCa-2 pancreatic tumors were treated with similar efficiency as PANC-1 tumors, although they differ significantly in sensitivity to viral lysis in cell cultures. When GLV-1h68 oncolytic viral therapy was used together with cisplatin or gemcitabine to treat PANC-1 tumors, the combination therapy resulted in enhanced and accelerated therapeutic results compared with the virus treatment alone. Profiling of proteins related to immune response revealed a significant proinflammatory immune response and marked activation of innate immunity in virus-colonized tumors. In conclusion, the GLV-1h68 strain showed outstanding therapeutic effects and a documented safety profile in mice, with great promise for future clinical development. [Mol Cancer Ther 2009;8(1):141–51]" @default.
• W2026108602 created "2016-06-24" @default.
• W2026108602 creator A5005824918 @default.
• W2026108602 creator A5013313803 @default.
• W2026108602 creator A5051659038 @default.
• W2026108602 creator A5053607274 @default.
• W2026108602 creator A5057322881 @default.
• W2026108602 creator A5069719395 @default.
• W2026108602 creator A5076597781 @default.
• W2026108602 date "2009-01-01" @default.
• W2026108602 modified "2023-10-11" @default.
• W2026108602 title "Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68" @default.
• W2026108602 cites W1814912217 @default.
• W2026108602 cites W1964170236 @default.
• W2026108602 cites W1965734230 @default.
• W2026108602 cites W1965830355 @default.
• W2026108602 cites W1968308458 @default.
• W2026108602 cites W1992753885 @default.
• W2026108602 cites W2021678023 @default.
• W2026108602 cites W2025034051 @default.
• W2026108602 cites W2047318784 @default.
• W2026108602 cites W2063066521 @default.
• W2026108602 cites W2065165441 @default.
• W2026108602 cites W2076674654 @default.
• W2026108602 cites W2080056304 @default.
• W2026108602 cites W2100342970 @default.
• W2026108602 cites W2107561601 @default.
• W2026108602 cites W2135047876 @default.
• W2026108602 cites W2136246490 @default.
• W2026108602 cites W2154400127 @default.
• W2026108602 cites W2158134441 @default.
• W2026108602 cites W2885912385 @default.
• W2026108602 cites W4234999757 @default.
• W2026108602 doi "https://doi.org/10.1158/1535-7163.mct-08-0533" @default.
• W2026108602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2664310" @default.
• W2026108602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19139123" @default.
• W2026108602 hasPublicationYear "2009" @default.
• W2026108602 type Work @default.
• W2026108602 sameAs 2026108602 @default.
• W2026108602 citedByCount "91" @default.
• W2026108602 countsByYear W20261086022012 @default.
• W2026108602 countsByYear W20261086022013 @default.
• W2026108602 countsByYear W20261086022014 @default.
• W2026108602 countsByYear W20261086022015 @default.
• W2026108602 countsByYear W20261086022016 @default.
• W2026108602 countsByYear W20261086022017 @default.
• W2026108602 countsByYear W20261086022018 @default.
• W2026108602 countsByYear W20261086022019 @default.
• W2026108602 countsByYear W20261086022020 @default.
• W2026108602 countsByYear W20261086022021 @default.
• W2026108602 countsByYear W20261086022022 @default.
• W2026108602 countsByYear W20261086022023 @default.
• W2026108602 crossrefType "journal-article" @default.
• W2026108602 hasAuthorship W2026108602A5005824918 @default.
• W2026108602 hasAuthorship W2026108602A5013313803 @default.
• W2026108602 hasAuthorship W2026108602A5051659038 @default.
• W2026108602 hasAuthorship W2026108602A5053607274 @default.
• W2026108602 hasAuthorship W2026108602A5057322881 @default.
• W2026108602 hasAuthorship W2026108602A5069719395 @default.
• W2026108602 hasAuthorship W2026108602A5076597781 @default.
• W2026108602 hasBestOaLocation W20261086021 @default.
• W2026108602 hasConcept C104317684 @default.
• W2026108602 hasConcept C121608353 @default.
• W2026108602 hasConcept C140704245 @default.
• W2026108602 hasConcept C159047783 @default.
• W2026108602 hasConcept C203014093 @default.
• W2026108602 hasConcept C2522874641 @default.
• W2026108602 hasConcept C2780210213 @default.
• W2026108602 hasConcept C2780931953 @default.
• W2026108602 hasConcept C2781356689 @default.
• W2026108602 hasConcept C40767141 @default.
• W2026108602 hasConcept C502942594 @default.
• W2026108602 hasConcept C54355233 @default.
• W2026108602 hasConcept C55493867 @default.
• W2026108602 hasConcept C82210918 @default.
• W2026108602 hasConcept C86803240 @default.
• W2026108602 hasConcept C8891405 @default.
• W2026108602 hasConceptScore W2026108602C104317684 @default.
• W2026108602 hasConceptScore W2026108602C121608353 @default.
• W2026108602 hasConceptScore W2026108602C140704245 @default.
• W2026108602 hasConceptScore W2026108602C159047783 @default.
• W2026108602 hasConceptScore W2026108602C203014093 @default.
• W2026108602 hasConceptScore W2026108602C2522874641 @default.
• W2026108602 hasConceptScore W2026108602C2780210213 @default.
• W2026108602 hasConceptScore W2026108602C2780931953 @default.
• W2026108602 hasConceptScore W2026108602C2781356689 @default.
• W2026108602 hasConceptScore W2026108602C40767141 @default.
• W2026108602 hasConceptScore W2026108602C502942594 @default.
• W2026108602 hasConceptScore W2026108602C54355233 @default.
• W2026108602 hasConceptScore W2026108602C55493867 @default.
• W2026108602 hasConceptScore W2026108602C82210918 @default.
• W2026108602 hasConceptScore W2026108602C86803240 @default.
• W2026108602 hasConceptScore W2026108602C8891405 @default.
• W2026108602 hasIssue "1" @default.
• W2026108602 hasLocation W20261086021 @default.
• W2026108602 hasLocation W20261086022 @default.
• W2026108602 hasLocation W20261086023 @default.
• W2026108602 hasLocation W20261086024 @default.

• next