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- W2026112079 abstract "A series of quinoxaline derivatives was prepared and evaluated for antitubercular, antibacterial and antifungal activities. The title compounds were prepared by condensation of substituted aromatic aldehydes and substituted acetophenones with 2-(3-methyl-2-oxoquinoxalin-1(2 H )-yl) acetohydrazide. Structures of all these compounds were confirmed by their spectral studies. Among synthesized compounds ( 4r, 4t, 4u, 4w and 4x ) have shown good anti tubercular activity (25 µg mL -1 ) when compared to reference drugs pyrazinamide (10 µg mL -1 ) and streptomycin (7.5 µg mL -1 ). In this study, few derivatives showed broad spectrum of antimicrobial activity at low concentration. The MICs (Minimum inhibitory concentration) of some compounds are 2-4 µg mL -1 ." @default.
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- W2026112079 date "2010-01-01" @default.
- W2026112079 modified "2023-09-27" @default.
- W2026112079 title "Synthesis and Biological Evaluation of 2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)-N'-(substituted phenyl-methyledene/ethylidene)acetohydrazides" @default.
- W2026112079 doi "https://doi.org/10.1155/2010/543125" @default.
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