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• W2026133902 endingPage "13690" @default.
• W2026133902 startingPage "13684" @default.
• W2026133902 abstract "Proopiomelanocortin (POMC) neurons have been intensively studied because of their essential role in regulating energy balance and body weight. Many effects of POMC neurons can be attributed to their release of cognate neuropeptides from secretory granules in axon terminals. However, these neurons also synaptically release non-peptide neurotransmitters. The aim of this study was to settle the controversy whether there are separate populations of POMC neurons that release GABA or glutamate. Transgenic mice expressing a red fluorescent protein [Discosoma red (DsRed)] driven by Pomc neuronal regulatory elements (POMC-DsRed) were crossed to mice that expressed green fluorescent protein (gfp) in GABAergic neurons (GAD67-gfp). Approximately 40% of POMC neurons in the arcuate nucleus of the double-transgenic mice expressed the GAD67-gfp transgene. In vitro neurotransmitter release was detected using whole-cell electrophysiologic recordings in cultured GAD67-gfp-positive and GAD67-gfp-negative POMC neurons that had formed recurrent synapses (autapses). Autapses from GAD67-gfp-positive neurons were uniformly GABAergic. In contrast, autapses from the GAD67-gfp-negative POMC neurons exclusively exhibited postsynaptic currents mediated by glutamate. Together, these results indicate that there are two subpopulations of POMC neurons in the arcuate nucleus differentiated by their amino acid neurotransmitter phenotype. Whole-cell voltage-clamp recordings from POMC neurons in live brain slices indicated that GABAergic and glutamatergic POMC neurons are under similar presynaptic and postsynaptic regulation, although the GABAergic POMC neurons are smaller and have higher input resistance. GABAergic and glutamatergic POMC neurons may mediate distinct aspects of POMC neuron function, including the regulation of energy homeostasis." @default.
• W2026133902 created "2016-06-24" @default.
• W2026133902 creator A5001765282 @default.
• W2026133902 creator A5001765898 @default.
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• W2026133902 creator A5059171771 @default.
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• W2026133902 date "2009-10-28" @default.
• W2026133902 modified "2023-10-18" @default.
• W2026133902 title "Proopiomelanocortin Expression in both GABA and Glutamate Neurons" @default.
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• W2026133902 doi "https://doi.org/10.1523/jneurosci.3770-09.2009" @default.
• W2026133902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2785088" @default.
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• W2026133902 hasPublicationYear "2009" @default.
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