Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026134248> ?p ?o ?g. }
- W2026134248 endingPage "999" @default.
- W2026134248 startingPage "992" @default.
- W2026134248 abstract "Nitric oxide (NO) is widely accepted as a central regulator of vascular tone and a vast array of other cardiovascular signaling mechanisms. An emerging player in these mechanisms is hemoglobin (Hb), an erythrocytic protein that serves as the archetypical model for an allosteric protein. Specifically, red blood cells (RBC) are suggested to be integral in matching blood flow to tissue oxygen demands. The mechanisms proposed involve the ability of Hb to sense changes in oxygen concentrations and coupling this process to modulating vascular NO levels. The molecular basis of these mechanisms remains under investigation, but is clearly diverse and discussed in this article from the basis of the blood flow responses to hypoxia. Another emerging theme in RBC biology is the role of these cells during inflammatory disease in which disease processes promote the interaction of vascular NO and the RBC. This is exemplified in hemolytic diseases, in which released Hb has drastic affects on vascular homeostasis mechanisms. Additionally, it is becoming evident that RBC express numerous molecules that mediate interactions with the extracellular matrix and cellular mediators of inflammation. The functional implications for such interactions remain unclear but highlight potential roles of the RBC in modulating inflammatory disease. Antioxid. Redox Signal. 6, 992–999." @default.
- W2026134248 created "2016-06-24" @default.
- W2026134248 creator A5006954987 @default.
- W2026134248 creator A5008369327 @default.
- W2026134248 creator A5021751784 @default.
- W2026134248 creator A5087867631 @default.
- W2026134248 date "2004-12-01" @default.
- W2026134248 modified "2023-10-15" @default.
- W2026134248 title "The Red Blood Cell and Vascular Function in Health and Disease" @default.
- W2026134248 cites W1507533499 @default.
- W2026134248 cites W1582167355 @default.
- W2026134248 cites W1589586351 @default.
- W2026134248 cites W162264688 @default.
- W2026134248 cites W1821918060 @default.
- W2026134248 cites W1834906675 @default.
- W2026134248 cites W1968470511 @default.
- W2026134248 cites W1973052344 @default.
- W2026134248 cites W1980840255 @default.
- W2026134248 cites W1984776459 @default.
- W2026134248 cites W1986079719 @default.
- W2026134248 cites W1986323106 @default.
- W2026134248 cites W1987033217 @default.
- W2026134248 cites W1987671956 @default.
- W2026134248 cites W1993827281 @default.
- W2026134248 cites W2001078662 @default.
- W2026134248 cites W2001182083 @default.
- W2026134248 cites W2001296234 @default.
- W2026134248 cites W2002812519 @default.
- W2026134248 cites W2002847421 @default.
- W2026134248 cites W2005187114 @default.
- W2026134248 cites W2008247353 @default.
- W2026134248 cites W2010520937 @default.
- W2026134248 cites W2013851960 @default.
- W2026134248 cites W2018380711 @default.
- W2026134248 cites W2019435702 @default.
- W2026134248 cites W2023500405 @default.
- W2026134248 cites W2028162035 @default.
- W2026134248 cites W2029491963 @default.
- W2026134248 cites W2033357754 @default.
- W2026134248 cites W2034188480 @default.
- W2026134248 cites W2034445068 @default.
- W2026134248 cites W2034919439 @default.
- W2026134248 cites W2035356593 @default.
- W2026134248 cites W2036715058 @default.
- W2026134248 cites W2039240565 @default.
- W2026134248 cites W2042631529 @default.
- W2026134248 cites W2044921286 @default.
- W2026134248 cites W2046327656 @default.
- W2026134248 cites W2046500825 @default.
- W2026134248 cites W2047568079 @default.
- W2026134248 cites W2050776161 @default.
- W2026134248 cites W2052608119 @default.
- W2026134248 cites W2054092506 @default.
- W2026134248 cites W2055713391 @default.
- W2026134248 cites W2056150843 @default.
- W2026134248 cites W2058137293 @default.
- W2026134248 cites W2059075159 @default.
- W2026134248 cites W2059446603 @default.
- W2026134248 cites W2076135408 @default.
- W2026134248 cites W2079775820 @default.
- W2026134248 cites W2086135343 @default.
- W2026134248 cites W2087992799 @default.
- W2026134248 cites W2093994279 @default.
- W2026134248 cites W2095688768 @default.
- W2026134248 cites W2106187279 @default.
- W2026134248 cites W2110264385 @default.
- W2026134248 cites W2118023300 @default.
- W2026134248 cites W2120182098 @default.
- W2026134248 cites W2126315219 @default.
- W2026134248 cites W2127322546 @default.
- W2026134248 cites W2127475487 @default.
- W2026134248 cites W2127479364 @default.
- W2026134248 cites W2127710249 @default.
- W2026134248 cites W2131700854 @default.
- W2026134248 cites W2141958278 @default.
- W2026134248 cites W2144096901 @default.
- W2026134248 cites W2146096871 @default.
- W2026134248 cites W2150449873 @default.
- W2026134248 cites W2151243449 @default.
- W2026134248 cites W2156411931 @default.
- W2026134248 cites W2163878933 @default.
- W2026134248 cites W2168545708 @default.
- W2026134248 cites W2229460713 @default.
- W2026134248 cites W4241694836 @default.
- W2026134248 doi "https://doi.org/10.1089/ars.2004.6.992" @default.
- W2026134248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15548896" @default.
- W2026134248 hasPublicationYear "2004" @default.
- W2026134248 type Work @default.
- W2026134248 sameAs 2026134248 @default.
- W2026134248 citedByCount "35" @default.
- W2026134248 countsByYear W20261342482012 @default.
- W2026134248 countsByYear W20261342482014 @default.
- W2026134248 countsByYear W20261342482015 @default.
- W2026134248 countsByYear W20261342482017 @default.
- W2026134248 countsByYear W20261342482018 @default.
- W2026134248 countsByYear W20261342482019 @default.
- W2026134248 countsByYear W20261342482020 @default.
- W2026134248 countsByYear W20261342482021 @default.