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- W2026148998 abstract "Depression of the vitamin K-dependent modulators of coagulation during the initial phase of oral anticoagulant therapy may lead to a transient hypercoagulable state and skin necrosis. We report a case of skin necrosis associated with inherited protein S deficiency following prolonged coumarin therapy. As a result of a stasis ulceration causing a rise in c4b binding protein and concurrent treatment with topical sulfonamide, we hypothesize that a precipitous decrease in free protein S led to skin necrosis. Progression of the necrosis was halted with unactivated prothrombin complex concentrate. This case confirms the rare association between coumarin induced skin necrosis and protein S deficiency and emphasizes potential drug interactions." @default.
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- W2026148998 date "1991-09-01" @default.
- W2026148998 modified "2023-10-17" @default.
- W2026148998 title "Skin necrosis following prolonged administration of coumarin in a patient with inherited protein S deficiency" @default.
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- W2026148998 doi "https://doi.org/10.1002/ajh.2830380111" @default.
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