Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026152261> ?p ?o ?g. }
- W2026152261 endingPage "4562" @default.
- W2026152261 startingPage "4549" @default.
- W2026152261 abstract "Abstract Tumor hypoxia drives metastatic progression, drug resistance, and posttreatment relapses, but how cancer cells adapt and evolve in response to hypoxic stress is not well understood. In this study, we address this question with the discovery that the receptor tyrosine kinase RON translocates into the nucleus of hypoxic cancer cells. In response to hypoxia, nuclear RON interacts with the hypoxia-inducible factor HIF-1α in a manner that relies on RON tyrosine kinase activity, binding to the c-JUN promoter and activating it. Mechanistic investigations revealed unexpectedly that nuclear RON played a more important role in activation of the c-JUN promoter than HIF-1α, leading to increased cell proliferation, survival adaptation, in vitro migration, and tumorigenicity under hypoxic conditions. Taken together, our results pointed to a novel function for RON as a transcriptional regulator that promotes the survival of cancer cells subjected to hypoxia. These results suggest novel implications for the use of small-molecule inhibitors or monoclonal antibodies targeting the RON kinase in the prevention or treatment of advanced cancer. Cancer Res; 74(16); 4549–62. ©2014 AACR." @default.
- W2026152261 created "2016-06-24" @default.
- W2026152261 creator A5007318688 @default.
- W2026152261 creator A5010238653 @default.
- W2026152261 creator A5010984446 @default.
- W2026152261 creator A5027236203 @default.
- W2026152261 creator A5072025450 @default.
- W2026152261 creator A5077974758 @default.
- W2026152261 creator A5080880299 @default.
- W2026152261 date "2014-08-13" @default.
- W2026152261 modified "2023-09-25" @default.
- W2026152261 title "Hypoxia Promotes Nuclear Translocation and Transcriptional Function in the Oncogenic Tyrosine Kinase RON" @default.
- W2026152261 cites W1493048246 @default.
- W2026152261 cites W1639582946 @default.
- W2026152261 cites W1963720869 @default.
- W2026152261 cites W1968366677 @default.
- W2026152261 cites W1991760434 @default.
- W2026152261 cites W2004118426 @default.
- W2026152261 cites W2005868479 @default.
- W2026152261 cites W2024903578 @default.
- W2026152261 cites W2027851837 @default.
- W2026152261 cites W2034269086 @default.
- W2026152261 cites W2051570504 @default.
- W2026152261 cites W2052183129 @default.
- W2026152261 cites W2055395862 @default.
- W2026152261 cites W2058338257 @default.
- W2026152261 cites W2082180864 @default.
- W2026152261 cites W2082483448 @default.
- W2026152261 cites W2085609942 @default.
- W2026152261 cites W2087032518 @default.
- W2026152261 cites W2087624913 @default.
- W2026152261 cites W2088498777 @default.
- W2026152261 cites W2092437474 @default.
- W2026152261 cites W2093742580 @default.
- W2026152261 cites W2105288740 @default.
- W2026152261 cites W2110296049 @default.
- W2026152261 cites W2114944688 @default.
- W2026152261 cites W2116184358 @default.
- W2026152261 cites W2121000910 @default.
- W2026152261 cites W2123173579 @default.
- W2026152261 cites W2124496728 @default.
- W2026152261 cites W2146930964 @default.
- W2026152261 cites W2148641706 @default.
- W2026152261 cites W2149011125 @default.
- W2026152261 cites W2157000380 @default.
- W2026152261 cites W2157259121 @default.
- W2026152261 cites W2157360354 @default.
- W2026152261 cites W2164300744 @default.
- W2026152261 cites W2165064874 @default.
- W2026152261 cites W2168472115 @default.
- W2026152261 cites W2168631000 @default.
- W2026152261 doi "https://doi.org/10.1158/0008-5472.can-13-3730" @default.
- W2026152261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24903148" @default.
- W2026152261 hasPublicationYear "2014" @default.
- W2026152261 type Work @default.
- W2026152261 sameAs 2026152261 @default.
- W2026152261 citedByCount "26" @default.
- W2026152261 countsByYear W20261522612015 @default.
- W2026152261 countsByYear W20261522612016 @default.
- W2026152261 countsByYear W20261522612017 @default.
- W2026152261 countsByYear W20261522612018 @default.
- W2026152261 countsByYear W20261522612019 @default.
- W2026152261 countsByYear W20261522612020 @default.
- W2026152261 countsByYear W20261522612021 @default.
- W2026152261 countsByYear W20261522612022 @default.
- W2026152261 countsByYear W20261522612023 @default.
- W2026152261 crossrefType "journal-article" @default.
- W2026152261 hasAuthorship W2026152261A5007318688 @default.
- W2026152261 hasAuthorship W2026152261A5010238653 @default.
- W2026152261 hasAuthorship W2026152261A5010984446 @default.
- W2026152261 hasAuthorship W2026152261A5027236203 @default.
- W2026152261 hasAuthorship W2026152261A5072025450 @default.
- W2026152261 hasAuthorship W2026152261A5077974758 @default.
- W2026152261 hasAuthorship W2026152261A5080880299 @default.
- W2026152261 hasBestOaLocation W20261522612 @default.
- W2026152261 hasConcept C101544691 @default.
- W2026152261 hasConcept C121608353 @default.
- W2026152261 hasConcept C178790620 @default.
- W2026152261 hasConcept C184235292 @default.
- W2026152261 hasConcept C185592680 @default.
- W2026152261 hasConcept C42362537 @default.
- W2026152261 hasConcept C502942594 @default.
- W2026152261 hasConcept C540031477 @default.
- W2026152261 hasConcept C54355233 @default.
- W2026152261 hasConcept C62478195 @default.
- W2026152261 hasConcept C7836513 @default.
- W2026152261 hasConcept C86803240 @default.
- W2026152261 hasConcept C95444343 @default.
- W2026152261 hasConcept C96232424 @default.
- W2026152261 hasConceptScore W2026152261C101544691 @default.
- W2026152261 hasConceptScore W2026152261C121608353 @default.
- W2026152261 hasConceptScore W2026152261C178790620 @default.
- W2026152261 hasConceptScore W2026152261C184235292 @default.
- W2026152261 hasConceptScore W2026152261C185592680 @default.
- W2026152261 hasConceptScore W2026152261C42362537 @default.
- W2026152261 hasConceptScore W2026152261C502942594 @default.
- W2026152261 hasConceptScore W2026152261C540031477 @default.
- W2026152261 hasConceptScore W2026152261C54355233 @default.