FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026155341> ?p ?o ?g. }

• W2026155341 endingPage "1227" @default.
• W2026155341 startingPage "1218" @default.
• W2026155341 abstract "Previously, we showed that the encapsulation and release properties of a liposomal ciprofloxacin formulation could be modified post manufacture, by addition of surfactant in concert with osmotic swelling of the liposomes. This strategy may provide more flexibility and convenience than the alternative of manufacturing multiple batches of liposomes differing in composition to cover a wide range of release profiles. The goal of this study was to develop a surfactant-associated liposomal ciprofloxacin (CFI) formulation possessing good long-term stability which could be delivered as an inhaled aerosol. Preparations of 12.5 mg/ml CFI containing 0.4% polysorbate 20 were formulated between pH 4.7 and 5.5. These formulations, before and after mesh nebulization, and after refrigerated storage for up to 2 years, were characterized in terms of liposome structure by cryogenic transmission electron microscopy (cryo-TEM) imaging, vesicle size by dynamic light scattering, pH, drug encapsulation by centrifugation-filtration, and in vitro release (IVR) performance. Within the narrower pH range of 4.9 to 5.2, these formulations retained their physicochemical stability after 2-year refrigerated storage, were robust to mesh nebulization, and formed respirable aerosols with a volume mean diameter (VMD) of 3.7 μm and a geometric standard deviation (GSD) of 1.7. This study demonstrates that it may be possible to provide a range of release profiles by simple addition of surfactant to a liposomal formulation post manufacture, and that these formulations may retain their physicochemical properties after long-term refrigerated storage and following aerosolization by mesh nebulizer." @default.
• W2026155341 created "2016-06-24" @default.
• W2026155341 creator A5005447050 @default.
• W2026155341 creator A5026820693 @default.
• W2026155341 creator A5056500136 @default.
• W2026155341 creator A5090727487 @default.
• W2026155341 date "2014-06-03" @default.
• W2026155341 modified "2023-10-12" @default.
• W2026155341 title "Aerosol Performance and Long-Term Stability of Surfactant-Associated Liposomal Ciprofloxacin Formulations with Modified Encapsulation and Release Properties" @default.
• W2026155341 cites W1980505972 @default.
• W2026155341 cites W1982181124 @default.
• W2026155341 cites W2001614120 @default.
• W2026155341 cites W2014784783 @default.
• W2026155341 cites W2020979302 @default.
• W2026155341 cites W2023045889 @default.
• W2026155341 cites W2040116689 @default.
• W2026155341 cites W2042612658 @default.
• W2026155341 cites W2048971450 @default.
• W2026155341 cites W2083336429 @default.
• W2026155341 cites W2106147991 @default.
• W2026155341 cites W2110155430 @default.
• W2026155341 cites W2113767091 @default.
• W2026155341 cites W2115591045 @default.
• W2026155341 cites W2119784812 @default.
• W2026155341 cites W2148928274 @default.
• W2026155341 cites W2157649059 @default.
• W2026155341 cites W2161605184 @default.
• W2026155341 cites W4300008029 @default.
• W2026155341 doi "https://doi.org/10.1208/s12249-014-0155-2" @default.
• W2026155341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4179662" @default.
• W2026155341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24889736" @default.
• W2026155341 hasPublicationYear "2014" @default.
• W2026155341 type Work @default.
• W2026155341 sameAs 2026155341 @default.
• W2026155341 citedByCount "15" @default.
• W2026155341 countsByYear W20261553412015 @default.
• W2026155341 countsByYear W20261553412016 @default.
• W2026155341 countsByYear W20261553412017 @default.
• W2026155341 countsByYear W20261553412018 @default.
• W2026155341 countsByYear W20261553412020 @default.
• W2026155341 countsByYear W20261553412021 @default.
• W2026155341 countsByYear W20261553412022 @default.
• W2026155341 crossrefType "journal-article" @default.
• W2026155341 hasAuthorship W2026155341A5005447050 @default.
• W2026155341 hasAuthorship W2026155341A5026820693 @default.
• W2026155341 hasAuthorship W2026155341A5056500136 @default.
• W2026155341 hasAuthorship W2026155341A5090727487 @default.
• W2026155341 hasBestOaLocation W20261553411 @default.
• W2026155341 hasConcept C105702510 @default.
• W2026155341 hasConcept C147789679 @default.
• W2026155341 hasConcept C178790620 @default.
• W2026155341 hasConcept C185154212 @default.
• W2026155341 hasConcept C185592680 @default.
• W2026155341 hasConcept C187530423 @default.
• W2026155341 hasConcept C2776954882 @default.
• W2026155341 hasConcept C2779820397 @default.
• W2026155341 hasConcept C2780352487 @default.
• W2026155341 hasConcept C42219234 @default.
• W2026155341 hasConcept C43617362 @default.
• W2026155341 hasConcept C55493867 @default.
• W2026155341 hasConcept C58226133 @default.
• W2026155341 hasConcept C71924100 @default.
• W2026155341 hasConcept C77281830 @default.
• W2026155341 hasConcept C82085835 @default.
• W2026155341 hasConceptScore W2026155341C105702510 @default.
• W2026155341 hasConceptScore W2026155341C147789679 @default.
• W2026155341 hasConceptScore W2026155341C178790620 @default.
• W2026155341 hasConceptScore W2026155341C185154212 @default.
• W2026155341 hasConceptScore W2026155341C185592680 @default.
• W2026155341 hasConceptScore W2026155341C187530423 @default.
• W2026155341 hasConceptScore W2026155341C2776954882 @default.
• W2026155341 hasConceptScore W2026155341C2779820397 @default.
• W2026155341 hasConceptScore W2026155341C2780352487 @default.
• W2026155341 hasConceptScore W2026155341C42219234 @default.
• W2026155341 hasConceptScore W2026155341C43617362 @default.
• W2026155341 hasConceptScore W2026155341C55493867 @default.
• W2026155341 hasConceptScore W2026155341C58226133 @default.
• W2026155341 hasConceptScore W2026155341C71924100 @default.
• W2026155341 hasConceptScore W2026155341C77281830 @default.
• W2026155341 hasConceptScore W2026155341C82085835 @default.
• W2026155341 hasIssue "5" @default.
• W2026155341 hasLocation W20261553411 @default.
• W2026155341 hasLocation W20261553412 @default.
• W2026155341 hasLocation W20261553413 @default.
• W2026155341 hasLocation W20261553414 @default.
• W2026155341 hasOpenAccess W2026155341 @default.
• W2026155341 hasPrimaryLocation W20261553411 @default.
• W2026155341 hasRelatedWork W2010086681 @default.
• W2026155341 hasRelatedWork W2037110469 @default.
• W2026155341 hasRelatedWork W2078871334 @default.
• W2026155341 hasRelatedWork W2121677473 @default.
• W2026155341 hasRelatedWork W2123528023 @default.
• W2026155341 hasRelatedWork W2174780790 @default.
• W2026155341 hasRelatedWork W2315984411 @default.
• W2026155341 hasRelatedWork W4210383442 @default.
• W2026155341 hasRelatedWork W4283170448 @default.
• W2026155341 hasRelatedWork W4306766609 @default.
• W2026155341 hasVolume "15" @default.

• next