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- W2026156675 abstract "From 1978 to 1995, 2165 patients (pts) were entered in trials of HF or AF RT. Two randomized trials in head and neck cancers accrued 867 pts: Protocol 22791 (356 pts, 1980–87) compared CF (70Gy/35–40 fr/7–8 wks) to HF (80.5Gy/70 fr/7 wks) in T2–T3, N0-N1 oropharyngeal carcinoma. Locoregional control (LRC) was higher (<i>P</i>=0.01) in HF versus CF. At 5 years, 56% of the pts are LRC free with HF versus 38% with CF. There was no difference in late normal tissue damage between the two treatment modalites. Protocol 22851 (511 pts, 1985–95) compared AF (72Gy/5) fr/5 wks) to CF (70Gy/35 fr/7 wks) in T2 T3 T4 head and neck cancers (hypopharynx excluded). Acute and late toxicity were increased in the AF arm. A better local control (<i>P</i>=0.01) and progression free survival (<i>P</i>=0.004) were achieved in the AF arm. These two trials show evidence of the major improvement brought by schemes based upon new radiological concepts. At 5 years, a 61% LRC is observed with AF versus 47% with AF. The progression free survival data suggest that the improvement in LRC contributed to a decrease in distant metastases in the AF arm." @default.
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- W2026156675 date "1995-11-01" @default.
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- W2026156675 title "321 Hyperfractionated (HF) and accelerated (AF) radiotherapy (RT) in head and neck cancers: Facts from trials, impact on standard practice" @default.
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