FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026158396> ?p ?o ?g. }

• W2026158396 endingPage "100" @default.
• W2026158396 startingPage "90" @default.
• W2026158396 abstract "The effect of intravenous (i.v.) serotonin (5-HT) on nociception and blood pressure was examined in male Sprague-Dawley rats. Intravenous 5-HT produced a dose-dependent (6-192 micrograms/kg, i.v.) inhibition of the nociceptive tail-flick (TF) reflex in lightly pentobarbital-anesthetized (ED50 = 40 micrograms/kg) and conscious rats (ED50 = 44 micrograms/kg). In the lightly pentobarbital-anesthetized rat, the blood pressure response to i.v. 5-HT was typically a triphasic response with a marked Bezold-Jarisch reflex-induced decrease in pressure (associated with a brief period of apnea) followed by a pressor phase and a subsequent delayed hypotension. In the conscious rat, the response was typically biphasic with the late hypotensive phase absent. A variety of anatomical and pharmacological manipulations were performed to characterize the 5-HT-induced inhibition of the TF reflex and associated changes in blood pressure. Prevention of 5-HT-induced reflex apnea by artificial ventilation did not affect inhibition of the TF reflex produced by 5-HT. Pharmacological manipulations were performed to mimic, as closely as possible, the acute increases and decreases in blood pressure associated with i.v. 5-HT. Nitroprusside (8 micrograms/kg, i.v.) produced a decrease in blood pressure of similar magnitude and rate as that associated with the Bezold-Jarisch reflex-induced decrease in pressure produced by 72 micrograms/kg 5-HT, but did not change TF latency from baseline. Similarly, acute increases in pressure produced by phenylephrine (8 micrograms/kg, i.v.), intended to mimic the secondary pressor effect of 5-HT, did not change TF latency. The short-acting ganglion blocker trimethaphan (5 mg/kg, i.v.) closely mimicked the late hypotensive phase produced by 5-HT, but again resulted in no change in TF latency. Pretreatment with the ganglion blocker chlorisondamine (2.5 mg/kg) abolished all depressor responses to 72 micrograms/kg 5-HT, but did not significantly affect the TF reflex. These results indicate that acute changes in blood pressure and respiration associated with i.v. 5-HT do not contribute to inhibition of the TF reflex. This conclusion was confirmed in experiments in which bilateral vagotomy abolished approximately 70% of the 5-HT-induced inhibition of the TF reflex (and all depressor responses), and resulted in a significantly greater pressor response. Finally, low thoracic spinal cord transection (T9-10) abolished the inhibition of the TF reflex produced by i.v. 5-HT. Therefore, 5-HT stimulates vagal afferents and inhibits the TF reflex by activating descending inhibitory systems from the brainstem.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2026158396 created "2016-06-24" @default.
• W2026158396 creator A5009931515 @default.
• W2026158396 creator A5026276050 @default.
• W2026158396 creator A5047846623 @default.
• W2026158396 creator A5067336969 @default.
• W2026158396 creator A5069114209 @default.
• W2026158396 date "1990-07-01" @default.
• W2026158396 modified "2023-09-27" @default.
• W2026158396 title "Vagal afferent-mediated inhibition of a nociceptive reflex by intravenous serotonin i the rat. I. Characterization" @default.
• W2026158396 cites W1565165145 @default.
• W2026158396 cites W160817884 @default.
• W2026158396 cites W1859201630 @default.
• W2026158396 cites W1964003759 @default.
• W2026158396 cites W1964087086 @default.
• W2026158396 cites W1964199017 @default.
• W2026158396 cites W1964931621 @default.
• W2026158396 cites W1966058845 @default.
• W2026158396 cites W1967354297 @default.
• W2026158396 cites W1969534967 @default.
• W2026158396 cites W1973396124 @default.
• W2026158396 cites W1974742465 @default.
• W2026158396 cites W1977202650 @default.
• W2026158396 cites W1980499989 @default.
• W2026158396 cites W1985210340 @default.
• W2026158396 cites W1989314580 @default.
• W2026158396 cites W1998615691 @default.
• W2026158396 cites W2001324810 @default.
• W2026158396 cites W2001979625 @default.
• W2026158396 cites W2002188348 @default.
• W2026158396 cites W2002316390 @default.
• W2026158396 cites W2003432589 @default.
• W2026158396 cites W2012253976 @default.
• W2026158396 cites W2023990353 @default.
• W2026158396 cites W2032822165 @default.
• W2026158396 cites W2037646830 @default.
• W2026158396 cites W2037994619 @default.
• W2026158396 cites W2042314767 @default.
• W2026158396 cites W2044178972 @default.
• W2026158396 cites W2052204014 @default.
• W2026158396 cites W2056271203 @default.
• W2026158396 cites W2060247222 @default.
• W2026158396 cites W2065507184 @default.
• W2026158396 cites W2069369658 @default.
• W2026158396 cites W2072070770 @default.
• W2026158396 cites W2073056198 @default.
• W2026158396 cites W2074160789 @default.
• W2026158396 cites W2075243069 @default.
• W2026158396 cites W2075484161 @default.
• W2026158396 cites W2076893174 @default.
• W2026158396 cites W2083865582 @default.
• W2026158396 cites W2085334441 @default.
• W2026158396 cites W2086669533 @default.
• W2026158396 cites W2089404417 @default.
• W2026158396 cites W2091576010 @default.
• W2026158396 cites W2109258596 @default.
• W2026158396 cites W2140285237 @default.
• W2026158396 cites W2180153748 @default.
• W2026158396 cites W2255469893 @default.
• W2026158396 cites W2256008282 @default.
• W2026158396 cites W2257426634 @default.
• W2026158396 cites W2296789677 @default.
• W2026158396 cites W2396235587 @default.
• W2026158396 cites W2409724843 @default.
• W2026158396 cites W2419274433 @default.
• W2026158396 cites W2419438452 @default.
• W2026158396 cites W2438723580 @default.
• W2026158396 cites W2948274817 @default.
• W2026158396 cites W656420001 @default.
• W2026158396 cites W85455198 @default.
• W2026158396 cites W2413053977 @default.
• W2026158396 doi "https://doi.org/10.1016/0006-8993(90)90496-x" @default.
• W2026158396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2400935" @default.
• W2026158396 hasPublicationYear "1990" @default.
• W2026158396 type Work @default.
• W2026158396 sameAs 2026158396 @default.
• W2026158396 citedByCount "42" @default.
• W2026158396 countsByYear W20261583962015 @default.
• W2026158396 countsByYear W20261583962021 @default.
• W2026158396 crossrefType "journal-article" @default.
• W2026158396 hasAuthorship W2026158396A5009931515 @default.
• W2026158396 hasAuthorship W2026158396A5026276050 @default.
• W2026158396 hasAuthorship W2026158396A5047846623 @default.
• W2026158396 hasAuthorship W2026158396A5067336969 @default.
• W2026158396 hasAuthorship W2026158396A5069114209 @default.
• W2026158396 hasConcept C126322002 @default.
• W2026158396 hasConcept C134018914 @default.
• W2026158396 hasConcept C15490471 @default.
• W2026158396 hasConcept C170493617 @default.
• W2026158396 hasConcept C185592680 @default.
• W2026158396 hasConcept C191237925 @default.
• W2026158396 hasConcept C195512701 @default.
• W2026158396 hasConcept C2775864247 @default.
• W2026158396 hasConcept C2776755955 @default.
• W2026158396 hasConcept C2777952589 @default.
• W2026158396 hasConcept C2777953023 @default.
• W2026158396 hasConcept C42219234 @default.
• W2026158396 hasConcept C42533223 @default.

• next