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- W2026158765 abstract "Speculations are developed for a mechanism by which oncogenic viruses can induce alterations in cells allowing them to express embryonic genes. It is suggested that if viral deoxyribonucleic acid, directly or via ribonucleic acid directed deoxyribonucleic acid polymerase activity becomes inserted at particular euchromatin — heterochromatin junctions of quasidifferentiated stem-like cells, then deheterochromatization may result, causing in turn derepression of genes for acidic protein phosphokinases. This sets into motion a series of events including altered acid protein repressors of embryonic genes which are repressed by uniquely weak type repressors. This explains how viruses can act as specific embryonic gene-inducing agents similar to chemical inducing agents such as the hepatocarcinogen ethinine." @default.
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- W2026158765 date "1979-03-01" @default.
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- W2026158765 title "Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: IV. The viruses" @default.
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- W2026158765 doi "https://doi.org/10.1016/0306-9877(79)90020-3" @default.
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