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- W2026168947 abstract "Abstract The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) and the hair-dye component 2,4-diaminoanisole (2,4-DAA) were studied for possible cytotoxic effects in rat hepatoma cells grown in culture and in suspensions of isolated rat hepatocytes. Cell growth of Reuber cells was inhibited by 50% at 50 μg/ml Tris-BP and 20 μg/ml 2,4-DAA, respectively. At 200 μg/ml Tris-BP protein synthesis in Reuber cells was reduced by 40%, whereas 50% inhibition of protein synthesis in isolated hepatocytes was seen at 100 μg/ml. IC50 of 2,4-DAA with respect to protein synthesis was found at 400 μg/ml in Reuber cells and at 3600 μg/ml in MH1C1 cells, whereas in the isolated hepatocytes IC50 was 650 μg/ml. DNA synthesis was inhibited by 50% at 225 μg/ml Tris-BP in Reuber cells. At 500 μg/ml 2,4-DAA DNA synthesis in Reuber and MH1C1 cells was inhibited by more than 80%." @default.
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- W2026168947 date "2009-03-13" @default.
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- W2026168947 title "Cytotoxic Effects of Tris (2,3-dibromopropyl) phosphate and 2,4-diaminoanisole" @default.
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- W2026168947 doi "https://doi.org/10.1111/j.1600-0773.1979.tb02331.x" @default.
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