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- W2026171504 startingPage "349" @default.
- W2026171504 abstract "Genetic susceptibility to scrapie is associated with polymorphisms in three different codons of the ovine prion protein (PrP) gene (136, 154, 171). Studies of PrP genotypes linked to scrapie have revealed the resistance of homozygous PrP ARR /PrP ARR animals and the high risk of PrP vRQ /PrP vRQ and PrP vRQ /PrP ARQ animals in scrapie‐affected flocks. The selection of Pr PAR /Pr PAR genotypes may therefore provide a strategy for controlling clinical scrapie. The genotypes of 1361 German breeding sheep from 15 different breeds in northern Germany were determined. Apart from the wildtype allele PrP ARQ , at least four mutually exclusive allelic variants were found. The greatest variability within the PrP gene was encountered in texel sheep, in which 14 PrP genotypes were found. In the important meat breeds, Suffolk, German whiteheaded mutton and German blackheaded mutton, the PrP ARR allele was predominant, and in these breeds the breeding of scrapie‐resistant pedigree flocks within four generations seems to be a feasible option. In the texel sheep, the German merino, the German milk and the German land sheep breeds, the frequency of the PrP ARR allele was much lower, and in several breeds no homozygous rams were available for breeding purposes. In these breeds the breeding strategy would depend on the number of heterozygous rams available, but resistant pedigree flocks could be achieved within nine generations." @default.
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- W2026171504 date "2001-09-01" @default.
- W2026171504 modified "2023-09-23" @default.
- W2026171504 title "PrP genotype frequencies in German breeding sheep and the potential to breed for resistance to scrapie" @default.
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- W2026171504 doi "https://doi.org/10.1136/vr.149.12.349" @default.
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