FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026172660> ?p ?o ?g. }

• W2026172660 endingPage "8409" @default.
• W2026172660 startingPage "8402" @default.
• W2026172660 abstract "Present interventions to repair severed peripheral nerves provide slow and poor early axonal regeneration, which may cause unsatisfactory functional reinnervation. To improve early axonal regeneration in a 10 mm rat sciatic nerve gap model, we developed collagen nerve conduits loaded with the synergistically acting glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF). For controlling the concomitant GDNF and NGF release, the collagen tubes were cross-linked by a dehydro-thermal treatment (110 degrees C; 20 mbar; 5 days) prior to impregnating the tubes with GDNF and NGF and by coating drug-loaded tubes with layers of poly(lactide-co-glycolide). The conduits made of cross-linked collagen released low initial amounts of GDNF and NGF (2% of both during first 3 days) and enhanced significantly the early (2 weeks) nerve regeneration in terms of axonal outgrowth and Schwann cell migration in a 10 mm rat sciatic nerve gap model, as compared to the conduits made of non-cross-linked collagen releasing higher initial amounts of GDNF and NGF (12-16% within 3 days), or those releasing GDNF alone. The enhancement of early axonal regeneration using controlled co-delivery of multiple synergistic neurotrophic factors is an important requisite for eventually establishing functional connections with the target organ." @default.
• W2026172660 created "2016-06-24" @default.
• W2026172660 creator A5006539804 @default.
• W2026172660 creator A5041403434 @default.
• W2026172660 creator A5056329950 @default.
• W2026172660 creator A5078926648 @default.
• W2026172660 creator A5091114828 @default.
• W2026172660 date "2010-11-01" @default.
• W2026172660 modified "2023-10-01" @default.
• W2026172660 title "Effect of controlled co-delivery of synergistic neurotrophic factors on early nerve regeneration in rats" @default.
• W2026172660 cites W1505236598 @default.
• W2026172660 cites W1531652687 @default.
• W2026172660 cites W1933310320 @default.
• W2026172660 cites W1943849675 @default.
• W2026172660 cites W1956978115 @default.
• W2026172660 cites W1965352187 @default.
• W2026172660 cites W1965538813 @default.
• W2026172660 cites W196582648 @default.
• W2026172660 cites W1967672185 @default.
• W2026172660 cites W1969914861 @default.
• W2026172660 cites W1971208141 @default.
• W2026172660 cites W1971644755 @default.
• W2026172660 cites W1975551679 @default.
• W2026172660 cites W1981223600 @default.
• W2026172660 cites W1984788897 @default.
• W2026172660 cites W1986235075 @default.
• W2026172660 cites W1989434542 @default.
• W2026172660 cites W1994452959 @default.
• W2026172660 cites W1995729951 @default.
• W2026172660 cites W2009078332 @default.
• W2026172660 cites W2015479943 @default.
• W2026172660 cites W2016470847 @default.
• W2026172660 cites W2018484185 @default.
• W2026172660 cites W2018946166 @default.
• W2026172660 cites W2021643587 @default.
• W2026172660 cites W2023341576 @default.
• W2026172660 cites W2023563139 @default.
• W2026172660 cites W2024599493 @default.
• W2026172660 cites W2028865228 @default.
• W2026172660 cites W2031656577 @default.
• W2026172660 cites W2039849887 @default.
• W2026172660 cites W2041462893 @default.
• W2026172660 cites W2051062618 @default.
• W2026172660 cites W2055954043 @default.
• W2026172660 cites W2059720153 @default.
• W2026172660 cites W2064963239 @default.
• W2026172660 cites W2065639432 @default.
• W2026172660 cites W2067642103 @default.
• W2026172660 cites W2069334439 @default.
• W2026172660 cites W2079860906 @default.
• W2026172660 cites W2086495566 @default.
• W2026172660 cites W2090036201 @default.
• W2026172660 cites W2092179822 @default.
• W2026172660 cites W2093229003 @default.
• W2026172660 cites W2095461390 @default.
• W2026172660 cites W2100169867 @default.
• W2026172660 cites W2104950498 @default.
• W2026172660 cites W2105454620 @default.
• W2026172660 cites W2114683341 @default.
• W2026172660 cites W2117806919 @default.
• W2026172660 cites W2130613687 @default.
• W2026172660 cites W2134678910 @default.
• W2026172660 cites W2143326638 @default.
• W2026172660 cites W2152216522 @default.
• W2026172660 cites W2154309821 @default.
• W2026172660 cites W4233074401 @default.
• W2026172660 doi "https://doi.org/10.1016/j.biomaterials.2010.07.052" @default.
• W2026172660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20692034" @default.
• W2026172660 hasPublicationYear "2010" @default.
• W2026172660 type Work @default.
• W2026172660 sameAs 2026172660 @default.
• W2026172660 citedByCount "81" @default.
• W2026172660 countsByYear W20261726602012 @default.
• W2026172660 countsByYear W20261726602013 @default.
• W2026172660 countsByYear W20261726602014 @default.
• W2026172660 countsByYear W20261726602015 @default.
• W2026172660 countsByYear W20261726602016 @default.
• W2026172660 countsByYear W20261726602017 @default.
• W2026172660 countsByYear W20261726602018 @default.
• W2026172660 countsByYear W20261726602019 @default.
• W2026172660 countsByYear W20261726602020 @default.
• W2026172660 countsByYear W20261726602021 @default.
• W2026172660 countsByYear W20261726602022 @default.
• W2026172660 countsByYear W20261726602023 @default.
• W2026172660 crossrefType "journal-article" @default.
• W2026172660 hasAuthorship W2026172660A5006539804 @default.
• W2026172660 hasAuthorship W2026172660A5041403434 @default.
• W2026172660 hasAuthorship W2026172660A5056329950 @default.
• W2026172660 hasAuthorship W2026172660A5078926648 @default.
• W2026172660 hasAuthorship W2026172660A5091114828 @default.
• W2026172660 hasConcept C105702510 @default.
• W2026172660 hasConcept C126322002 @default.
• W2026172660 hasConcept C136940099 @default.
• W2026172660 hasConcept C160539049 @default.
• W2026172660 hasConcept C170493617 @default.
• W2026172660 hasConcept C171056886 @default.
• W2026172660 hasConcept C185856081 @default.
• W2026172660 hasConcept C192562407 @default.

• next