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• W2026175417 endingPage "177" @default.
• W2026175417 startingPage "173" @default.
• W2026175417 abstract "We have recently shown that connexin 43 (Cx43), a major gap junction protein in osteoblasts, is expressed with an increase in cell density (CHIBA, H. et al. (1993). Cell Struc. Funct., 18: 419-426). In the present study, we examined what kinds of hormones and cytokines regulate the gap junction protein in osteoblastic cells, using a human osteoblastic cell line (SV-HFO) after reaching a confluent density to avoid influence of cell proliferation. Either retinoic acid (RA) or transforming growth factor-beta 1 (TGF-beta 1) induced the Cx43 expression of SV-HFO cells, as revealed by Northern blot analysis and immunocytochemistry. These modulators also increased gap junctional intercellular communication, in terms of the extent of dye transfer. On the other hand, 1 alpha, 25-dihydroxyvitamin D3 did not influence the Cx43 expression and gap junctional intercellular communication of the cells. These results suggest that RA and TGF-beta might maintain bone tissue as an organized tissue in vivo by increasing intercellular communication of osteoblastic cells." @default.
• W2026175417 created "2016-06-24" @default.
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• W2026175417 date "1994-01-01" @default.
• W2026175417 modified "2023-10-09" @default.
• W2026175417 title "Hormonal Regulation of Connexin 43 Expression and Gap Junctional Communication in Human Osteoblastic Cells." @default.
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• W2026175417 doi "https://doi.org/10.1247/csf.19.173" @default.
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