Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026181645> ?p ?o ?g. }
- W2026181645 endingPage "6" @default.
- W2026181645 startingPage "1" @default.
- W2026181645 abstract "There is increasing evidence demonstrating that the renoprotective effects of mineralocorticoid receptor (MR) blockade are independent of the effects exerted by renin-angiotensin inhibitors. MR is expressed not only in tubular cells but also in other renal cells including glomerular mesangial cells, podocytes, and renal interstitial fibroblasts. Animal experiments have shown that MR blockers prevent aldosterone-induced proteinuria, glomerular injury, and tubulointerstitial fibrosis. In vitro studies have also demonstrated that MR blockers inhibit aldosterone-induced renal cell damage. Recent clinical studies have shown that treatment with MR blockers attenuates the development of proteinuria in patients with chronic kidney disease (CKD) and hypertension, independent of changes in blood pressure. In some cases, MR blockers elicit potent renoprotective effects in conditions where aldosterone levels are not elevated. These data suggest that treatment with MR blockers may possibly present an effective therapeutic strategy for patients with CKD." @default.
- W2026181645 created "2016-06-24" @default.
- W2026181645 creator A5004704949 @default.
- W2026181645 creator A5049861668 @default.
- W2026181645 creator A5068866929 @default.
- W2026181645 creator A5091907930 @default.
- W2026181645 date "2009-01-01" @default.
- W2026181645 modified "2023-10-16" @default.
- W2026181645 title "Drug Discovery for Overcoming Chronic Kidney Disease (CKD): Pharmacological Effects of Mineralocorticoid-Receptor Blockers" @default.
- W2026181645 cites W1963910855 @default.
- W2026181645 cites W1963930171 @default.
- W2026181645 cites W1964101426 @default.
- W2026181645 cites W1964527653 @default.
- W2026181645 cites W1964833810 @default.
- W2026181645 cites W1968999388 @default.
- W2026181645 cites W1969355655 @default.
- W2026181645 cites W1970209851 @default.
- W2026181645 cites W1970221667 @default.
- W2026181645 cites W1971543621 @default.
- W2026181645 cites W1983528779 @default.
- W2026181645 cites W2000812251 @default.
- W2026181645 cites W2003508199 @default.
- W2026181645 cites W2012714305 @default.
- W2026181645 cites W2014888569 @default.
- W2026181645 cites W2019270553 @default.
- W2026181645 cites W2020811647 @default.
- W2026181645 cites W2020877653 @default.
- W2026181645 cites W2035210500 @default.
- W2026181645 cites W2039893332 @default.
- W2026181645 cites W2045535261 @default.
- W2026181645 cites W2046604144 @default.
- W2026181645 cites W2051678468 @default.
- W2026181645 cites W2056602728 @default.
- W2026181645 cites W2059722418 @default.
- W2026181645 cites W2061018844 @default.
- W2026181645 cites W2070775917 @default.
- W2026181645 cites W2072525233 @default.
- W2026181645 cites W2074391878 @default.
- W2026181645 cites W2075323044 @default.
- W2026181645 cites W2080115055 @default.
- W2026181645 cites W2086655048 @default.
- W2026181645 cites W2090526184 @default.
- W2026181645 cites W2101948924 @default.
- W2026181645 cites W2104170721 @default.
- W2026181645 cites W2106836840 @default.
- W2026181645 cites W2107418117 @default.
- W2026181645 cites W2109888686 @default.
- W2026181645 cites W2114271630 @default.
- W2026181645 cites W2114614037 @default.
- W2026181645 cites W2115608897 @default.
- W2026181645 cites W2116163401 @default.
- W2026181645 cites W2118932957 @default.
- W2026181645 cites W2123778248 @default.
- W2026181645 cites W2126174661 @default.
- W2026181645 cites W2126628424 @default.
- W2026181645 cites W2128236156 @default.
- W2026181645 cites W2129223025 @default.
- W2026181645 cites W2132715232 @default.
- W2026181645 cites W2143777411 @default.
- W2026181645 cites W2145569553 @default.
- W2026181645 cites W2147273166 @default.
- W2026181645 cites W2148959930 @default.
- W2026181645 cites W2149390033 @default.
- W2026181645 cites W2152094259 @default.
- W2026181645 cites W2152187665 @default.
- W2026181645 cites W2154797232 @default.
- W2026181645 cites W2156121263 @default.
- W2026181645 cites W2158912789 @default.
- W2026181645 cites W2159020799 @default.
- W2026181645 cites W2161474086 @default.
- W2026181645 cites W2161727113 @default.
- W2026181645 cites W2163156090 @default.
- W2026181645 cites W2165098078 @default.
- W2026181645 cites W2303651371 @default.
- W2026181645 cites W2323458614 @default.
- W2026181645 cites W4231659835 @default.
- W2026181645 cites W4254741601 @default.
- W2026181645 doi "https://doi.org/10.1254/jphs.08r12fm" @default.
- W2026181645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19151533" @default.
- W2026181645 hasPublicationYear "2009" @default.
- W2026181645 type Work @default.
- W2026181645 sameAs 2026181645 @default.
- W2026181645 citedByCount "27" @default.
- W2026181645 countsByYear W20261816452012 @default.
- W2026181645 countsByYear W20261816452014 @default.
- W2026181645 countsByYear W20261816452015 @default.
- W2026181645 countsByYear W20261816452016 @default.
- W2026181645 countsByYear W20261816452018 @default.
- W2026181645 countsByYear W20261816452019 @default.
- W2026181645 crossrefType "journal-article" @default.
- W2026181645 hasAuthorship W2026181645A5004704949 @default.
- W2026181645 hasAuthorship W2026181645A5049861668 @default.
- W2026181645 hasAuthorship W2026181645A5068866929 @default.
- W2026181645 hasAuthorship W2026181645A5091907930 @default.
- W2026181645 hasBestOaLocation W20261816451 @default.
- W2026181645 hasConcept C126322002 @default.
- W2026181645 hasConcept C126894567 @default.
- W2026181645 hasConcept C134018914 @default.