FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026190337> ?p ?o ?g. }

• W2026190337 endingPage "1792" @default.
• W2026190337 startingPage "1787" @default.
• W2026190337 abstract "We have previously reported that a 7-d pretreatment with hexarelin, a synthetic ligand of the GH secretagogue receptor (GHS-R), largely prevented damages induced by ischemia and reperfusion in isolated rat hearts. Our aim was to ascertain whether ghrelin, an endogenous ligand of the GHS-R, is physiologically endowed with cardioprotective activity. Hypophysectomized rats were treated in vivo for 7 d with either ghrelin (320 μg/kg) or hexarelin (80 μg/kg), and their hearts were subjected in vitro to the ischemia and reperfusion procedure. Ghrelin was far less effective than hexarelin in preventing increases in left ventricular end-diastolic pressure (15% and 60% protection for ghrelin and hexarelin, respectively), coronary perfusion pressure (10% and 45% reduction), and release of creatine kinase in the heart perfusate (15% and 55% reduction). In the second experiment, normal rats were passively immunized against ghrelin for 21 d before the ischemia and reperfusion procedure. In these isolated hearts, the ischemia-reperfusion damage was not significantly increased compared with control rats. After hypophysectomy, CD36 mRNA levels significantly increased, whereas those of atrial natriuretic factor significantly decreased. We conclude that: 1) ghrelin plays a minor role in the control of heart function; and 2) hexarelin effects are mediated in part by the GHS-R and largely by interactions with the CD36." @default.
• W2026190337 created "2016-06-24" @default.
• W2026190337 creator A5010566842 @default.
• W2026190337 creator A5017160244 @default.
• W2026190337 creator A5018953836 @default.
• W2026190337 creator A5026741989 @default.
• W2026190337 creator A5032227666 @default.
• W2026190337 creator A5038399658 @default.
• W2026190337 creator A5039478018 @default.
• W2026190337 creator A5062690635 @default.
• W2026190337 creator A5069735395 @default.
• W2026190337 creator A5076609343 @default.
• W2026190337 date "2003-05-01" @default.
• W2026190337 modified "2023-09-25" @default.
• W2026190337 title "Ghrelin Plays a Minor Role in the Physiological Control of Cardiac Function in the Rat" @default.
• W2026190337 cites W1901716085 @default.
• W2026190337 cites W1968237482 @default.
• W2026190337 cites W1969000927 @default.
• W2026190337 cites W1988146076 @default.
• W2026190337 cites W2009707449 @default.
• W2026190337 cites W2009908559 @default.
• W2026190337 cites W2021130150 @default.
• W2026190337 cites W2032673083 @default.
• W2026190337 cites W2038472138 @default.
• W2026190337 cites W2040304426 @default.
• W2026190337 cites W2043750439 @default.
• W2026190337 cites W2050197669 @default.
• W2026190337 cites W2053680491 @default.
• W2026190337 cites W2077472475 @default.
• W2026190337 cites W2083751629 @default.
• W2026190337 cites W2089567200 @default.
• W2026190337 cites W2091593585 @default.
• W2026190337 cites W2124549557 @default.
• W2026190337 cites W2128594838 @default.
• W2026190337 cites W2129700656 @default.
• W2026190337 cites W2134812217 @default.
• W2026190337 cites W2149074941 @default.
• W2026190337 cites W2153245546 @default.
• W2026190337 cites W2159515861 @default.
• W2026190337 cites W2161559015 @default.
• W2026190337 cites W2163865122 @default.
• W2026190337 cites W340450340 @default.
• W2026190337 doi "https://doi.org/10.1210/en.2002-221048" @default.
• W2026190337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12697684" @default.
• W2026190337 hasPublicationYear "2003" @default.
• W2026190337 type Work @default.
• W2026190337 sameAs 2026190337 @default.
• W2026190337 citedByCount "62" @default.
• W2026190337 countsByYear W20261903372012 @default.
• W2026190337 countsByYear W20261903372013 @default.
• W2026190337 countsByYear W20261903372014 @default.
• W2026190337 countsByYear W20261903372015 @default.
• W2026190337 countsByYear W20261903372017 @default.
• W2026190337 countsByYear W20261903372018 @default.
• W2026190337 countsByYear W20261903372019 @default.
• W2026190337 countsByYear W20261903372020 @default.
• W2026190337 countsByYear W20261903372021 @default.
• W2026190337 crossrefType "journal-article" @default.
• W2026190337 hasAuthorship W2026190337A5010566842 @default.
• W2026190337 hasAuthorship W2026190337A5017160244 @default.
• W2026190337 hasAuthorship W2026190337A5018953836 @default.
• W2026190337 hasAuthorship W2026190337A5026741989 @default.
• W2026190337 hasAuthorship W2026190337A5032227666 @default.
• W2026190337 hasAuthorship W2026190337A5038399658 @default.
• W2026190337 hasAuthorship W2026190337A5039478018 @default.
• W2026190337 hasAuthorship W2026190337A5062690635 @default.
• W2026190337 hasAuthorship W2026190337A5069735395 @default.
• W2026190337 hasAuthorship W2026190337A5076609343 @default.
• W2026190337 hasBestOaLocation W20261903371 @default.
• W2026190337 hasConcept C126322002 @default.
• W2026190337 hasConcept C134018914 @default.
• W2026190337 hasConcept C146957229 @default.
• W2026190337 hasConcept C150903083 @default.
• W2026190337 hasConcept C170493617 @default.
• W2026190337 hasConcept C185592680 @default.
• W2026190337 hasConcept C207001950 @default.
• W2026190337 hasConcept C2779168441 @default.
• W2026190337 hasConcept C2779357093 @default.
• W2026190337 hasConcept C2780104272 @default.
• W2026190337 hasConcept C2780161494 @default.
• W2026190337 hasConcept C36880943 @default.
• W2026190337 hasConcept C541997718 @default.
• W2026190337 hasConcept C71315377 @default.
• W2026190337 hasConcept C71924100 @default.
• W2026190337 hasConcept C86803240 @default.
• W2026190337 hasConceptScore W2026190337C126322002 @default.
• W2026190337 hasConceptScore W2026190337C134018914 @default.
• W2026190337 hasConceptScore W2026190337C146957229 @default.
• W2026190337 hasConceptScore W2026190337C150903083 @default.
• W2026190337 hasConceptScore W2026190337C170493617 @default.
• W2026190337 hasConceptScore W2026190337C185592680 @default.
• W2026190337 hasConceptScore W2026190337C207001950 @default.
• W2026190337 hasConceptScore W2026190337C2779168441 @default.
• W2026190337 hasConceptScore W2026190337C2779357093 @default.
• W2026190337 hasConceptScore W2026190337C2780104272 @default.
• W2026190337 hasConceptScore W2026190337C2780161494 @default.
• W2026190337 hasConceptScore W2026190337C36880943 @default.
• W2026190337 hasConceptScore W2026190337C541997718 @default.

• next