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• W2026199709 abstract "Abstract 1. 1. The minimal dose of acetylcholine required to produce second degree A-V block (the minimal standardizing dose) was determined in thirty-one dogs. Although the minimal standardizing dose varies widely from animal to animal, it remains relatively constant for the same animal over long periods of time. The minimal standardizing dose bears a crude relationship to the hemoglobin level. Doses ten times and twenty times the minimal standardizing dose were also given. With such doses auricular fibrillation occurred in approximately 50 per cent of the animals tested. 2. 2. Anemia was produced by phenylhydrazine, n-propyl disulfide, and hemorrhage. An increased sensitivity toward the development of A-V block and auricular fibrillation which roughly paralleled the course of the anemia was observed. Fifty per cent of the dogs which did not fibrillate with control injections of acetylcholine fibrillated following the onset of the anemia. Animals which fibrillated with control injections fibrillated during anemia with smaller doses of acetylcholine. 3. 3. It is suggested that the increased sensitivity of the heart to acetylcholine in anemia is due to anoxia of the myocardium. Decreased concentration of effectiveness of cholinesterase may also play a role. 4. 4. In dogs in which acetylcholine causes auricular fibrillation, there is a semidirect relationship between the dosage of acetylcholine given and the length of time during which the auricles fibrillate. There is also a relationship between the magnitude of the dose and the length of time during which the A-V block persists. 5. 5. The development of auricular fibrillation was preceded in almost every instance by the occurrence of intra-auricular block and A-V block. It is suggested on the basis of the contour of our records and in support of previous reports from this department that auricular re-entry is the mechanism of the genesis of auricular fibrillation. 6. 6. Electrocardiographic changes seen after the administration of acetylcholine included changes in the contour of the P waves and the T waves and shifts in the P-Q and S-T segments. Arrhythmias seen included auricular fibrillation and flutter, ventricular tachycardia, auricular and ventricular premature systoles, nodal rhythm, and A-V dissociation." @default.
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• W2026199709 title "The role of anemia in the experimental production of heart block and auricular fibrillation in the dog" @default.
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• W2026199709 doi "https://doi.org/10.1016/0002-8703(49)90528-1" @default.
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