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- W2026200312 abstract "Glucocorticoids play an essential role in the regulation of key physiological processes, including immunomodulation, brain function, energy metabolism, electrolyte balance and blood pressure. Exposure to naturally occurring compounds or industrial chemicals that impair glucocorticoid action may contribute to the increasing incidence of cognitive deficits, immune disorders and metabolic diseases. Potentially, glucocorticoid disruptors can interfere with various steps of hormone action, e.g. hormone synthesis, binding to plasma proteins, delivery to target cells, pre-receptor regulation of the ratio of active versus inactive hormones, glucocorticoid receptor (GR) function, or export and degradation of glucocorticoids. Several recent studies indicate that such chemicals exist and that some of them can cause multiple toxic effects by interfering with different steps of hormone action. For example, increasing evidence suggests that organotins disturb glucocorticoid action by altering the function of factors that regulate the expression of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) pre-receptor enzymes, by direct inhibition of 11beta-HSD2-dependent inactivation of glucocorticoids, and by blocking GR activation. These observations emphasize on the complexity of the toxic effects caused by such compounds and on the need of suitable test systems to assess their effects on each relevant step." @default.
- W2026200312 created "2016-06-24" @default.
- W2026200312 creator A5049947406 @default.
- W2026200312 creator A5052563992 @default.
- W2026200312 creator A5057477992 @default.
- W2026200312 creator A5061155886 @default.
- W2026200312 date "2006-12-01" @default.
- W2026200312 modified "2023-10-18" @default.
- W2026200312 title "Disruption of glucocorticoid action by environmental chemicals: Potential mechanisms and relevance" @default.
- W2026200312 cites W1564985705 @default.
- W2026200312 cites W1591075433 @default.
- W2026200312 cites W1964300143 @default.
- W2026200312 cites W1966668423 @default.
- W2026200312 cites W1966915255 @default.
- W2026200312 cites W1967784136 @default.
- W2026200312 cites W1970064359 @default.
- W2026200312 cites W1970166627 @default.
- W2026200312 cites W1970762661 @default.
- W2026200312 cites W1974086094 @default.
- W2026200312 cites W1974740534 @default.
- W2026200312 cites W1976058073 @default.
- W2026200312 cites W1978718098 @default.
- W2026200312 cites W1979089442 @default.
- W2026200312 cites W1984925676 @default.
- W2026200312 cites W1986667734 @default.
- W2026200312 cites W1986707574 @default.
- W2026200312 cites W1989119734 @default.
- W2026200312 cites W1991185023 @default.
- W2026200312 cites W1991349305 @default.
- W2026200312 cites W1993237941 @default.
- W2026200312 cites W1994646358 @default.
- W2026200312 cites W1995290986 @default.
- W2026200312 cites W1998298246 @default.
- W2026200312 cites W2000565365 @default.
- W2026200312 cites W2008532902 @default.
- W2026200312 cites W2012673559 @default.
- W2026200312 cites W2013641711 @default.
- W2026200312 cites W2015838103 @default.
- W2026200312 cites W2016125985 @default.
- W2026200312 cites W2016909719 @default.
- W2026200312 cites W2018952780 @default.
- W2026200312 cites W2019164791 @default.
- W2026200312 cites W2025098860 @default.
- W2026200312 cites W2025126559 @default.
- W2026200312 cites W2025643678 @default.
- W2026200312 cites W2028975577 @default.
- W2026200312 cites W2032558538 @default.
- W2026200312 cites W2033296044 @default.
- W2026200312 cites W2035617742 @default.
- W2026200312 cites W2036239608 @default.
- W2026200312 cites W2038386757 @default.
- W2026200312 cites W2038893397 @default.
- W2026200312 cites W2040399039 @default.
- W2026200312 cites W2040466319 @default.
- W2026200312 cites W2042614655 @default.
- W2026200312 cites W2043110076 @default.
- W2026200312 cites W2043255571 @default.
- W2026200312 cites W2043322496 @default.
- W2026200312 cites W2044804886 @default.
- W2026200312 cites W2046399147 @default.
- W2026200312 cites W2046405586 @default.
- W2026200312 cites W2048195605 @default.
- W2026200312 cites W2050698392 @default.
- W2026200312 cites W2053131174 @default.
- W2026200312 cites W2055001133 @default.
- W2026200312 cites W2059532543 @default.
- W2026200312 cites W2062859153 @default.
- W2026200312 cites W2065950115 @default.
- W2026200312 cites W2066748372 @default.
- W2026200312 cites W2067020163 @default.
- W2026200312 cites W2069513152 @default.
- W2026200312 cites W2071689617 @default.
- W2026200312 cites W2073417824 @default.
- W2026200312 cites W2074467897 @default.
- W2026200312 cites W2074575589 @default.
- W2026200312 cites W2075770595 @default.
- W2026200312 cites W2077495154 @default.
- W2026200312 cites W2081045438 @default.
- W2026200312 cites W2082948795 @default.
- W2026200312 cites W2085609196 @default.
- W2026200312 cites W2087645102 @default.
- W2026200312 cites W2089792717 @default.
- W2026200312 cites W2096570309 @default.
- W2026200312 cites W2098299168 @default.
- W2026200312 cites W2102335700 @default.
- W2026200312 cites W2106335160 @default.
- W2026200312 cites W2109429565 @default.
- W2026200312 cites W2111546909 @default.
- W2026200312 cites W2114231575 @default.
- W2026200312 cites W2117268230 @default.
- W2026200312 cites W2119251936 @default.
- W2026200312 cites W2119646277 @default.
- W2026200312 cites W2120543890 @default.
- W2026200312 cites W2127764698 @default.
- W2026200312 cites W2127969574 @default.
- W2026200312 cites W2133964366 @default.
- W2026200312 cites W2134563310 @default.
- W2026200312 cites W2139883678 @default.