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- W2026202479 abstract "Abstract Introduction Randomized clinical trials are considered the gold standard for evidence-based practices but strict inclusion and exclusion criteria, costs to perform them and the time required to design and complete them may limit generalizability, followup and timeliness. Observational studies based on well designed, large volume patient registries may be more flexible in that scope. Such registries can be modified with time to incorporate new treatments as they emerge. Methods We describe the design, objectives, funding mechanisms and results to date of the major prostate cancer registries in the United States, highlighting as examples PCOS, CaPSURE™, PROST-QA, CEASAR, MUSIC and AQUA. Results Registries and collaborations have provided valuable knowledge for prostate cancer regarding oncologic and health related quality of life outcomes among treatments, changes in disease prevalence, staging, national practice trends and health service utilization. Conclusions While there are important limitations to observational data, registries will continue to have an important and growing role in advancing prostate cancer care as a complement to data from clinical trials and traditional cohort studies." @default.
- W2026202479 created "2016-06-24" @default.
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- W2026202479 date "2014-11-01" @default.
- W2026202479 modified "2023-09-26" @default.
- W2026202479 title "National Prostate Cancer Registries: Contemporary Trends of Prostate Cancer in the United States" @default.
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- W2026202479 doi "https://doi.org/10.1016/j.urpr.2014.07.005" @default.
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