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- W2026211601 abstract "Rat brain SAM levels were markedly increased after methionine administration, whereas the convulsant, L-methionine-dl-sulphoximine (MSO), produced a 35 per cent decrease in whole brain content of S-adenosyl-L-methionine (SAM). When methionine was given in combination with MSO, SAM levels were not decreased. Studies on the regional distribution of SAM revealed only a small variation between regions (from 24 nmol/g in midbrain to 49-5 nmol/g in striatum). SAM levels were reduced by about 50 per cent in the cerebellum, striatum, cortex and hippocampus 3 and 6 h after MSO. It is proposed that abberant cerebral methylation processes may be involved in the genesis of the MSO seizure." @default.
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- W2026211601 date "1975-01-01" @default.
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- W2026211601 title "EFFECT OF METHIONINE AND METHIONINE SULPHOXIMINE ON RAT BRAIN S-ADENOSYL METHIONINE LEVELS" @default.
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- W2026211601 doi "https://doi.org/10.1111/j.1471-4159.1975.tb07628.x" @default.
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