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• W2026219098 abstract "Mild stress-induced hormesis represents a promising strategy for targeting the age-related accumulation of molecular damage and, therefore, for preventing diseases and achieving healthy aging. Fruits, vegetables, and spices contain a wide variety of hormetic phytochemicals, which may explain the beneficial health effects associated with the consumption of these dietary components. In the present study, the induction of cellular antioxidant defenses by the phenolic diterpenes carnosic acid (CA) and carnosol (CS) were studied in normal human skin fibroblasts, and insights into the aging process at the cellular level investigated. We observed that CA and CS induced several cytoprotective enzymes and antioxidant defenses in human fibroblasts, whose induction was dependent on the cellular redox state for CS and associated with Nrf2 signaling for both compounds. The stress response elicited by preincubation with CS conferred a cytoprotective action against a following oxidant challenge with tert-butyl hydroperoxide, confirming its hormetic effect. Preincubation of normal fibroblasts with CS also protected against hydrogen peroxide-induced premature senescence. Furthermore, cultivation of middle passage normal human skin fibroblasts in the presence of CS ameliorated the physiological state of cells during replicative senescence. Our results support the view that mild stress-induced antioxidant defenses by CS can confer stress tolerance in normal cells and may have important implications in the promotion of healthy aging." @default.
• W2026219098 created "2016-06-24" @default.
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• W2026219098 date "2015-06-01" @default.
• W2026219098 modified "2023-10-17" @default.
• W2026219098 title "Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence" @default.
• W2026219098 cites W1964041047 @default.
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• W2026219098 cites W1976070906 @default.
• W2026219098 cites W1977394099 @default.
• W2026219098 cites W1978772332 @default.
• W2026219098 cites W1978865937 @default.
• W2026219098 cites W1982660847 @default.
• W2026219098 cites W1983378779 @default.
• W2026219098 cites W1984085714 @default.
• W2026219098 cites W1991460472 @default.
• W2026219098 cites W1998026347 @default.
• W2026219098 cites W2011482325 @default.
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• W2026219098 cites W2021143006 @default.
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• W2026219098 cites W2030963645 @default.
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• W2026219098 doi "https://doi.org/10.1016/j.freeradbiomed.2015.02.022" @default.
• W2026219098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25744415" @default.
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