FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026236688> ?p ?o ?g. }

• W2026236688 endingPage "559" @default.
• W2026236688 startingPage "549" @default.
• W2026236688 abstract "Objective Increases in adrenergic activity are associated with stress, anxiety, and other psychiatric, neurological, and medical disorders. To improve understanding of normal CNS adrenergic function, CBF responses to adrenergic stimulation were determined. Methods Using PET, the CBF changes after intravenous yohimbine, an α2-adrenoreceptor antagonist that produces adrenergic activation, were compared with placebo in nine healthy humans. Heart rate, blood pressure, Paco2, plasma catecholamines, and symptom responses were also determined. Results Among nonscan variables, yohimbine produced significant symptom increases (including a panic attack in one subject), a decrease in Paco2 due to hyperventilation, increases in systolic and diastolic blood pressure, and a trend toward a significant norepinephrine increase. Among scan results, yohimbine produced a significant decrease in whole-brain absolute CBF; regional decreases were greatest in cortical areas. Medial frontal cortex, thalamus, insular cortex, and cerebellum showed significant increases after normalization to whole brain. Medial frontal CBF change was correlated with increases in anxiety. A panic attack produced an increase instead of a decrease in whole-brain CBF. Factors potentially contributing to the observed CBF changes were critically reviewed. Specific regional increases were most likely due in large part to activation produced by adrenergically induced anxiety and visceral symptoms. Conclusions This study supports the relationship of anxiety and interoceptive processes with medial frontal, insular, and thalamic activation and provides a baseline for comparison of normal yohimbine-induced CNS adrenergic activation, adrenergically-based symptoms, and other markers of adrenergic function to stress, emotion, and the adrenergic pathophysiologies of various CNS-related disorders." @default.
• W2026236688 created "2016-06-24" @default.
• W2026236688 creator A5007318813 @default.
• W2026236688 creator A5016000824 @default.
• W2026236688 creator A5053750375 @default.
• W2026236688 creator A5074512402 @default.
• W2026236688 date "2000-07-01" @default.
• W2026236688 modified "2023-10-13" @default.
• W2026236688 title "Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans" @default.
• W2026236688 cites W1525298240 @default.
• W2026236688 cites W1625910023 @default.
• W2026236688 cites W16603568 @default.
• W2026236688 cites W1773001224 @default.
• W2026236688 cites W1826329209 @default.
• W2026236688 cites W1967418759 @default.
• W2026236688 cites W1968821557 @default.
• W2026236688 cites W1973293496 @default.
• W2026236688 cites W1974235453 @default.
• W2026236688 cites W1974250880 @default.
• W2026236688 cites W1975458527 @default.
• W2026236688 cites W1976658908 @default.
• W2026236688 cites W1984593818 @default.
• W2026236688 cites W1989235729 @default.
• W2026236688 cites W1992099487 @default.
• W2026236688 cites W1992329618 @default.
• W2026236688 cites W1994401248 @default.
• W2026236688 cites W1995446935 @default.
• W2026236688 cites W1996652179 @default.
• W2026236688 cites W1999201555 @default.
• W2026236688 cites W1999722313 @default.
• W2026236688 cites W2005499716 @default.
• W2026236688 cites W2006050855 @default.
• W2026236688 cites W2009210592 @default.
• W2026236688 cites W2009973874 @default.
• W2026236688 cites W2011606453 @default.
• W2026236688 cites W2011836504 @default.
• W2026236688 cites W2012298299 @default.
• W2026236688 cites W2014641957 @default.
• W2026236688 cites W2014775156 @default.
• W2026236688 cites W2016447905 @default.
• W2026236688 cites W2031636627 @default.
• W2026236688 cites W2032865772 @default.
• W2026236688 cites W2038782045 @default.
• W2026236688 cites W2039043072 @default.
• W2026236688 cites W2042348492 @default.
• W2026236688 cites W2043889644 @default.
• W2026236688 cites W2045320365 @default.
• W2026236688 cites W2047568428 @default.
• W2026236688 cites W2049489255 @default.
• W2026236688 cites W2051691068 @default.
• W2026236688 cites W2052394570 @default.
• W2026236688 cites W2052493353 @default.
• W2026236688 cites W2052731679 @default.
• W2026236688 cites W2056541881 @default.
• W2026236688 cites W2060194941 @default.
• W2026236688 cites W2060657584 @default.
• W2026236688 cites W2065338158 @default.
• W2026236688 cites W2073366799 @default.
• W2026236688 cites W2075759181 @default.
• W2026236688 cites W2076521045 @default.
• W2026236688 cites W2077654529 @default.
• W2026236688 cites W2082808024 @default.
• W2026236688 cites W2083302038 @default.
• W2026236688 cites W2084574844 @default.
• W2026236688 cites W2084960362 @default.
• W2026236688 cites W2085924185 @default.
• W2026236688 cites W2092520870 @default.
• W2026236688 cites W2094357416 @default.
• W2026236688 cites W2096091161 @default.
• W2026236688 cites W2111416664 @default.
• W2026236688 cites W2112268199 @default.
• W2026236688 cites W2118406111 @default.
• W2026236688 cites W2124913096 @default.
• W2026236688 cites W2147984201 @default.
• W2026236688 cites W2152953741 @default.
• W2026236688 cites W2160527423 @default.
• W2026236688 cites W2161562068 @default.
• W2026236688 cites W2169230464 @default.
• W2026236688 cites W2169985903 @default.
• W2026236688 cites W2327845547 @default.
• W2026236688 cites W2395089870 @default.
• W2026236688 cites W2406909777 @default.
• W2026236688 cites W2512799920 @default.
• W2026236688 cites W4231646181 @default.
• W2026236688 doi "https://doi.org/10.1097/00006842-200007000-00014" @default.
• W2026236688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10949101" @default.
• W2026236688 hasPublicationYear "2000" @default.
• W2026236688 type Work @default.
• W2026236688 sameAs 2026236688 @default.
• W2026236688 citedByCount "53" @default.
• W2026236688 countsByYear W20262366882012 @default.
• W2026236688 countsByYear W20262366882013 @default.
• W2026236688 countsByYear W20262366882014 @default.
• W2026236688 countsByYear W20262366882015 @default.
• W2026236688 countsByYear W20262366882016 @default.
• W2026236688 countsByYear W20262366882017 @default.
• W2026236688 countsByYear W20262366882018 @default.
• W2026236688 countsByYear W20262366882020 @default.

• next