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- W2026247922 abstract "Drug developments in the vitamin D field have continued to focus on structure-function studies of analogs produced by chemically modifying the structure of 1α,25-dihydroxyvitamin D3 (1,25-D3) and its metabolites. Direct structural information gleaned from X-ray crystallographic or NMR studies regarding the ligand-receptor complex and other guest-host systems, which are likely involved in initiating biologic responses, also offers potential insight into drug design. Evidence has accrued suggesting that topologically different conformers of 1,25-D3 may bind to proteins in different ways, including the induction of different conformations of protein. This paper concerns our progress on the chemical synthesis of analogs (e.g. ansa-steroids, suprasterols, vinylallenes and other analogs) conformationally locked or at least rotationally restricted to mimic higher energy conformers of 1,25-D3." @default.
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- W2026247922 date "2001-03-01" @default.
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- W2026247922 title "Conformationally restricted mimics of vitamin D rotamers" @default.
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- W2026247922 doi "https://doi.org/10.1016/s0039-128x(00)00147-1" @default.
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