FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026256053> ?p ?o ?g. }

• W2026256053 endingPage "1601" @default.
• W2026256053 startingPage "1593" @default.
• W2026256053 abstract "We set out to determine the expression profiles of glycoproteins possessing N-acetyllactosamine, a precursor carbohydrate of sialyl Le x , during colorectal cancer development. We immunohistochemically analyzed the distribution of N-acetyllactosamine as well as of β4GalT-I, a member of the β1,4-galactosyltransferase family responsible for N-acetyllactosamine biosynthesis, in normal mucosa and in adenoma and carcinoma of the human colorectum. Using monoclonal antibody H11, N-acetyllactosamine was barely detectable in the normal mucosa. In low-grade adenoma, however, N-acetyllactosamine was weakly but definitely expressed on the cell surface, and its expression level was moderately increased in high-grade adenoma and markedly increased in carcinoma in situ as well as in advanced carcinoma. To detect β4GalT-I, we used a newly developed polyclonal antibody (designated A18G), which is specific for the stem region of human β4GalT-I. Faint expression of β4GalT-I was detectable in normal mucosa, and the expression level was moderately increased in low-grade adenoma and in high-grade adenoma and markedly increased in carcinoma in situ and advanced carcinoma. The expression of N-acetyllactosamine was highly correlated with the expression of β4GalT-I in these tumor cells. These results indicate that the expression level of β4GalT-I is apparently enhanced during tumorigenesis in the colorectum and that β4GalT-I mostly directs the carcinoma-associated expression of N-acetyllactosamine on the colorectal tumor cell surface." @default.
• W2026256053 created "2016-06-24" @default.
• W2026256053 creator A5006762365 @default.
• W2026256053 creator A5013168337 @default.
• W2026256053 creator A5030497460 @default.
• W2026256053 creator A5037900150 @default.
• W2026256053 creator A5043021883 @default.
• W2026256053 creator A5054897759 @default.
• W2026256053 creator A5075232587 @default.
• W2026256053 date "1999-12-01" @default.
• W2026256053 modified "2023-10-18" @default.
• W2026256053 title "Expression of <i>N</i>-acetyllactosamine and β1,4-Galactosyltransferase (β4GalT-I) During Adenoma-Carcinoma Sequence in the Human Colorectum" @default.
• W2026256053 cites W1482004139 @default.
• W2026256053 cites W1500163587 @default.
• W2026256053 cites W1594682500 @default.
• W2026256053 cites W1622325070 @default.
• W2026256053 cites W1861181542 @default.
• W2026256053 cites W1988581072 @default.
• W2026256053 cites W1997379663 @default.
• W2026256053 cites W2004481610 @default.
• W2026256053 cites W2010218012 @default.
• W2026256053 cites W2012756328 @default.
• W2026256053 cites W2014964973 @default.
• W2026256053 cites W2022797612 @default.
• W2026256053 cites W2024879590 @default.
• W2026256053 cites W2038000069 @default.
• W2026256053 cites W2039115186 @default.
• W2026256053 cites W2040739287 @default.
• W2026256053 cites W2049579277 @default.
• W2026256053 cites W2058142169 @default.
• W2026256053 cites W2060937867 @default.
• W2026256053 cites W2062221655 @default.
• W2026256053 cites W2068415554 @default.
• W2026256053 cites W2070329791 @default.
• W2026256053 cites W2070338538 @default.
• W2026256053 cites W2073322512 @default.
• W2026256053 cites W2076519306 @default.
• W2026256053 cites W2079042043 @default.
• W2026256053 cites W2085402247 @default.
• W2026256053 cites W2101108802 @default.
• W2026256053 cites W2122551579 @default.
• W2026256053 cites W2139664241 @default.
• W2026256053 cites W2333723852 @default.
• W2026256053 doi "https://doi.org/10.1177/002215549904701211" @default.
• W2026256053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10567443" @default.
• W2026256053 hasPublicationYear "1999" @default.
• W2026256053 type Work @default.
• W2026256053 sameAs 2026256053 @default.
• W2026256053 citedByCount "24" @default.
• W2026256053 countsByYear W20262560532012 @default.
• W2026256053 countsByYear W20262560532014 @default.
• W2026256053 countsByYear W20262560532015 @default.
• W2026256053 countsByYear W20262560532017 @default.
• W2026256053 countsByYear W20262560532021 @default.
• W2026256053 countsByYear W20262560532022 @default.
• W2026256053 countsByYear W20262560532023 @default.
• W2026256053 crossrefType "journal-article" @default.
• W2026256053 hasAuthorship W2026256053A5006762365 @default.
• W2026256053 hasAuthorship W2026256053A5013168337 @default.
• W2026256053 hasAuthorship W2026256053A5030497460 @default.
• W2026256053 hasAuthorship W2026256053A5037900150 @default.
• W2026256053 hasAuthorship W2026256053A5043021883 @default.
• W2026256053 hasAuthorship W2026256053A5054897759 @default.
• W2026256053 hasAuthorship W2026256053A5075232587 @default.
• W2026256053 hasBestOaLocation W20262560531 @default.
• W2026256053 hasConcept C121608353 @default.
• W2026256053 hasConcept C126322002 @default.
• W2026256053 hasConcept C142724271 @default.
• W2026256053 hasConcept C159654299 @default.
• W2026256053 hasConcept C203014093 @default.
• W2026256053 hasConcept C204232928 @default.
• W2026256053 hasConcept C2777428134 @default.
• W2026256053 hasConcept C2777546739 @default.
• W2026256053 hasConcept C2777661416 @default.
• W2026256053 hasConcept C526805850 @default.
• W2026256053 hasConcept C542903549 @default.
• W2026256053 hasConcept C555283112 @default.
• W2026256053 hasConcept C71924100 @default.
• W2026256053 hasConcept C86803240 @default.
• W2026256053 hasConceptScore W2026256053C121608353 @default.
• W2026256053 hasConceptScore W2026256053C126322002 @default.
• W2026256053 hasConceptScore W2026256053C142724271 @default.
• W2026256053 hasConceptScore W2026256053C159654299 @default.
• W2026256053 hasConceptScore W2026256053C203014093 @default.
• W2026256053 hasConceptScore W2026256053C204232928 @default.
• W2026256053 hasConceptScore W2026256053C2777428134 @default.
• W2026256053 hasConceptScore W2026256053C2777546739 @default.
• W2026256053 hasConceptScore W2026256053C2777661416 @default.
• W2026256053 hasConceptScore W2026256053C526805850 @default.
• W2026256053 hasConceptScore W2026256053C542903549 @default.
• W2026256053 hasConceptScore W2026256053C555283112 @default.
• W2026256053 hasConceptScore W2026256053C71924100 @default.
• W2026256053 hasConceptScore W2026256053C86803240 @default.
• W2026256053 hasIssue "12" @default.
• W2026256053 hasLocation W20262560531 @default.
• W2026256053 hasLocation W20262560532 @default.
• W2026256053 hasOpenAccess W2026256053 @default.
• W2026256053 hasPrimaryLocation W20262560531 @default.

• next