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- W2026257591 abstract "Blood pressure control in mild and moderate hypertension may reduce morbidity and mortality. On the other hand, antihypertensive drugs may cause adverse metabolic, electrolyte, neural and hemodynamic alterations that detract from their effectiveness. The effect of hydrochlorothiazide (HCTZ) on some of these factors was compared with that of HCTZ and a sympatholytic drug in 20 hypertensive patients with left ventricular hypertrophy and retinopathy. HCTZ controlled blood pressure at rest and during maximum treadmill exercise (−12 mm Hg systolic and diastolic pressure (p <0.05), reduced left ventricular mass by 7% (p <0.05) and lessened aerobic impairment at maximum treadmill exercise by 45% (p < 0.05). These effects were further improved after “neural blockade.” A potential adverse effect of HCTZ—hypokalemia (−0.6 mEq/liter, p <0.01)—and the associated incidence of ectopy during effort (50%) were lessened after neutralizing neural tone. Combination therapy with low-dose diuretic and sympatholytic drugs was effective and well tolerated in patients with cardiac and vascular sequelae of moderately severe hypertension." @default.
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- W2026257591 date "1985-08-01" @default.
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- W2026257591 title "Effects of exercise on blood pressure, plasma catecholamines, potassium and the electrocardiogram after diuretic and neural-blocking therapy for moderate hypertension" @default.
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- W2026257591 doi "https://doi.org/10.1016/0002-9149(85)91114-2" @default.
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