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• W2026289277 endingPage "12141" @default.
• W2026289277 startingPage "12138" @default.
• W2026289277 abstract "A new fluorescence method has been developed for DNA detection at room temperature in a sensitive, selective, economical, and real-time manner that interfaces the superiority of a molecular beacon in mismatch discrimination with the light-harvesting property of water-soluble conjugated polyelectrolytes. The probe solution contains a cationic conjugated polyelectrolyte (PFP-NMe3+), a molecular beacon with a five base pairs double-stranded stem labeled at the 5'-terminus with fluorescein (DNA P-Fl), and ethidium bromide (EB, a specific intercalator of dsDNA). The electrostatic interactions between DNA P-Fl and PFP-NMe3+ keep them in close proximity, facilitating the fluorescence resonance energy transfer (FRET) from PFP-NMe3+ to fluorescein. Upon adding a complementary strand to the probe solution, the conformation of DNA P-Fl transits into dsDNA followed by the intercalation of EB into the grooves. Two-step FRET, from PFP-NMe3+ to DNA P-Fl (FRET-1), followed by FRET from DNA P-Fl to EB (FRET-2) takes place. In view of the observed fluorescein or EB emission changes, DNA can be detected in aqueous solution. Because the base mismatch in target DNA inhibits the transition of DNA P-Fl from the stem-loop to duplex structure, single nucleotide mismatch can be clearly detected." @default.
• W2026289277 created "2016-06-24" @default.
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• W2026289277 date "2008-10-04" @default.
• W2026289277 modified "2023-09-24" @default.
• W2026289277 title "Cationic Conjugated Polyelectrolyte/Molecular Beacon Complex for Sensitive, Sequence-Specific, Real-Time DNA Detection" @default.
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• W2026289277 doi "https://doi.org/10.1021/la802932t" @default.
• W2026289277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18834161" @default.
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