FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026294309> ?p ?o ?g. }

• W2026294309 endingPage "e60939" @default.
• W2026294309 startingPage "e60939" @default.
• W2026294309 abstract "Obesity is an important risk factor for colon cancer in humans, and numerous studies have shown that a high fat diet enhances colon cancer development. As both increased adiposity and high fat diet can promote tumorigenesis, we examined the effect of diet-induced obesity, without ongoing high fat diet, on colon tumor development. C57BL/6J male mice were fed regular chow or high fat diet for 8 weeks. Diets were either maintained or switched resulting in four experimental groups: regular chow (R), high fat diet (H), regular chow switched to high fat diet (RH), and high fat diet switched to regular chow (HR). Mice were then administered azoxymethane to induce colon tumors. Tumor incidence and multiplicity were dramatically smaller in the R group relative to all groups that received high fat diet at any point. The effect of obesity on colon tumors could not be explained by differences in aberrant crypt foci number. Moreover, diet did not alter colonic expression of pro-inflammatory cytokines tumor necrosis factor-α, interleukin-6, interleukin-1β, and interferon-γ, which were measured immediately after azoxymethane treatment. Crypt apoptosis and proliferation, which were measured at the same time, were increased in the HR relative to all other groups. Our results suggest that factors associated with obesity - independently of ongoing high fat diet and obesity - promote tumor development because HR group animals had significantly more tumors than R group, and these mice were fed the same regular chow throughout the entire carcinogenic period. Moreover, there was no difference in the number of aberrant crypt foci between these groups, and thus the effect of obesity appears to be on subsequent stages of tumor development when early preneoplastic lesions transition into adenomas." @default.
• W2026294309 created "2016-06-24" @default.
• W2026294309 creator A5008873320 @default.
• W2026294309 creator A5013390858 @default.
• W2026294309 creator A5014760553 @default.
• W2026294309 creator A5034318752 @default.
• W2026294309 creator A5055001871 @default.
• W2026294309 creator A5064104324 @default.
• W2026294309 date "2013-04-03" @default.
• W2026294309 modified "2023-09-24" @default.
• W2026294309 title "Diet-Induced Obesity Promotes Colon Tumor Development in Azoxymethane-Treated Mice" @default.
• W2026294309 cites W1597583781 @default.
• W2026294309 cites W1974033843 @default.
• W2026294309 cites W1985223982 @default.
• W2026294309 cites W1993852503 @default.
• W2026294309 cites W1995293206 @default.
• W2026294309 cites W2000054651 @default.
• W2026294309 cites W2001258296 @default.
• W2026294309 cites W2009857926 @default.
• W2026294309 cites W2037295839 @default.
• W2026294309 cites W2041262630 @default.
• W2026294309 cites W2051504401 @default.
• W2026294309 cites W2053020515 @default.
• W2026294309 cites W2054801123 @default.
• W2026294309 cites W2070001214 @default.
• W2026294309 cites W2086648828 @default.
• W2026294309 cites W2090413626 @default.
• W2026294309 cites W2096541155 @default.
• W2026294309 cites W2098049779 @default.
• W2026294309 cites W2098510562 @default.
• W2026294309 cites W2102402916 @default.
• W2026294309 cites W2111334716 @default.
• W2026294309 cites W2115129277 @default.
• W2026294309 cites W2121527286 @default.
• W2026294309 cites W2143426053 @default.
• W2026294309 cites W2145562168 @default.
• W2026294309 cites W2149573313 @default.
• W2026294309 cites W2151401596 @default.
• W2026294309 cites W2153051732 @default.
• W2026294309 cites W2153383900 @default.
• W2026294309 cites W2160952640 @default.
• W2026294309 cites W2171157803 @default.
• W2026294309 doi "https://doi.org/10.1371/journal.pone.0060939" @default.
• W2026294309 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3616169" @default.
• W2026294309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23560112" @default.
• W2026294309 hasPublicationYear "2013" @default.
• W2026294309 type Work @default.
• W2026294309 sameAs 2026294309 @default.
• W2026294309 citedByCount "40" @default.
• W2026294309 countsByYear W20262943092013 @default.
• W2026294309 countsByYear W20262943092014 @default.
• W2026294309 countsByYear W20262943092015 @default.
• W2026294309 countsByYear W20262943092016 @default.
• W2026294309 countsByYear W20262943092017 @default.
• W2026294309 countsByYear W20262943092018 @default.
• W2026294309 countsByYear W20262943092019 @default.
• W2026294309 countsByYear W20262943092020 @default.
• W2026294309 countsByYear W20262943092021 @default.
• W2026294309 countsByYear W20262943092022 @default.
• W2026294309 countsByYear W20262943092023 @default.
• W2026294309 crossrefType "journal-article" @default.
• W2026294309 hasAuthorship W2026294309A5008873320 @default.
• W2026294309 hasAuthorship W2026294309A5013390858 @default.
• W2026294309 hasAuthorship W2026294309A5014760553 @default.
• W2026294309 hasAuthorship W2026294309A5034318752 @default.
• W2026294309 hasAuthorship W2026294309A5055001871 @default.
• W2026294309 hasAuthorship W2026294309A5064104324 @default.
• W2026294309 hasBestOaLocation W20262943091 @default.
• W2026294309 hasConcept C121608353 @default.
• W2026294309 hasConcept C126322002 @default.
• W2026294309 hasConcept C134018914 @default.
• W2026294309 hasConcept C17991360 @default.
• W2026294309 hasConcept C2778452354 @default.
• W2026294309 hasConcept C2780669762 @default.
• W2026294309 hasConcept C3018440083 @default.
• W2026294309 hasConcept C511355011 @default.
• W2026294309 hasConcept C526805850 @default.
• W2026294309 hasConcept C555283112 @default.
• W2026294309 hasConcept C66090201 @default.
• W2026294309 hasConcept C71924100 @default.
• W2026294309 hasConcept C86803240 @default.
• W2026294309 hasConceptScore W2026294309C121608353 @default.
• W2026294309 hasConceptScore W2026294309C126322002 @default.
• W2026294309 hasConceptScore W2026294309C134018914 @default.
• W2026294309 hasConceptScore W2026294309C17991360 @default.
• W2026294309 hasConceptScore W2026294309C2778452354 @default.
• W2026294309 hasConceptScore W2026294309C2780669762 @default.
• W2026294309 hasConceptScore W2026294309C3018440083 @default.
• W2026294309 hasConceptScore W2026294309C511355011 @default.
• W2026294309 hasConceptScore W2026294309C526805850 @default.
• W2026294309 hasConceptScore W2026294309C555283112 @default.
• W2026294309 hasConceptScore W2026294309C66090201 @default.
• W2026294309 hasConceptScore W2026294309C71924100 @default.
• W2026294309 hasConceptScore W2026294309C86803240 @default.
• W2026294309 hasIssue "4" @default.
• W2026294309 hasLocation W20262943091 @default.
• W2026294309 hasLocation W20262943092 @default.
• W2026294309 hasLocation W20262943093 @default.

• next