Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026296040> ?p ?o ?g. }
- W2026296040 endingPage "681" @default.
- W2026296040 startingPage "673" @default.
- W2026296040 abstract "Addition of dexamethasone (Dex) to human mesenchymal stem cells (hMSCs) resulted in a 16-fold increase in human bone morphogenetic protein-6 (hBMP-6) mRNA levels 24 h after treatment. Evaluation of luciferase expression after transfection of HeLa cells with hBMP-6 promoter/luciferase reporter constructs indicated that the hBMP-6 promoter activity was contained in a 268-bp region (−1051 to −784 where +1 is the translation start site) over 600 bases 5′ to that previously published. It further showed that the promoter activity is regulated by glucocorticoid treatment. Analysis of RNA from hMSCs and HeLa cells by primer extension, RNase protection, and 5′ RACE further narrowed the location of the transcription start site to an 84-bp region (−940 to −857). To determine whether this start site was regulated in hMSCs, hBMP-6 mRNA levels in control and Dex-treated cells were quantitated by RT-PCR using one primer set in the translated region of the gene and one located just 3′ of the 84-bp region. Both primer sets showed hBMP-6 mRNA levels approximately 16- to 22-fold higher in the Dex-treated cells, demonstrating that hBMP-6 transcription is being regulated by glucocorticoids in the pluripotent hMSCs at the upstream transcription start site." @default.
- W2026296040 created "2016-06-24" @default.
- W2026296040 creator A5002606028 @default.
- W2026296040 creator A5002847881 @default.
- W2026296040 creator A5034025244 @default.
- W2026296040 creator A5042115463 @default.
- W2026296040 creator A5055151607 @default.
- W2026296040 creator A5060883124 @default.
- W2026296040 date "2004-09-01" @default.
- W2026296040 modified "2023-10-17" @default.
- W2026296040 title "Glucocorticoid regulation of human BMP-6 transcription" @default.
- W2026296040 cites W1522773084 @default.
- W2026296040 cites W1717444875 @default.
- W2026296040 cites W1833613269 @default.
- W2026296040 cites W1962351050 @default.
- W2026296040 cites W1965174761 @default.
- W2026296040 cites W1966639987 @default.
- W2026296040 cites W1968822620 @default.
- W2026296040 cites W1977950302 @default.
- W2026296040 cites W1979529284 @default.
- W2026296040 cites W1980722886 @default.
- W2026296040 cites W1986469118 @default.
- W2026296040 cites W1987557547 @default.
- W2026296040 cites W1990854759 @default.
- W2026296040 cites W1996381409 @default.
- W2026296040 cites W2011575748 @default.
- W2026296040 cites W2021405025 @default.
- W2026296040 cites W2038917241 @default.
- W2026296040 cites W2055110202 @default.
- W2026296040 cites W2073130464 @default.
- W2026296040 cites W2085463192 @default.
- W2026296040 cites W2092603902 @default.
- W2026296040 cites W2104752640 @default.
- W2026296040 cites W2121848695 @default.
- W2026296040 cites W2131598671 @default.
- W2026296040 cites W2132251976 @default.
- W2026296040 cites W2144268541 @default.
- W2026296040 cites W2164486535 @default.
- W2026296040 cites W4235060429 @default.
- W2026296040 cites W4239316747 @default.
- W2026296040 cites W4247203390 @default.
- W2026296040 cites W4295836001 @default.
- W2026296040 doi "https://doi.org/10.1016/j.bone.2004.04.017" @default.
- W2026296040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15336603" @default.
- W2026296040 hasPublicationYear "2004" @default.
- W2026296040 type Work @default.
- W2026296040 sameAs 2026296040 @default.
- W2026296040 citedByCount "23" @default.
- W2026296040 countsByYear W20262960402012 @default.
- W2026296040 countsByYear W20262960402014 @default.
- W2026296040 countsByYear W20262960402019 @default.
- W2026296040 countsByYear W20262960402020 @default.
- W2026296040 crossrefType "journal-article" @default.
- W2026296040 hasAuthorship W2026296040A5002606028 @default.
- W2026296040 hasAuthorship W2026296040A5002847881 @default.
- W2026296040 hasAuthorship W2026296040A5034025244 @default.
- W2026296040 hasAuthorship W2026296040A5042115463 @default.
- W2026296040 hasAuthorship W2026296040A5055151607 @default.
- W2026296040 hasAuthorship W2026296040A5060883124 @default.
- W2026296040 hasConcept C101762097 @default.
- W2026296040 hasConcept C104317684 @default.
- W2026296040 hasConcept C105580179 @default.
- W2026296040 hasConcept C111335760 @default.
- W2026296040 hasConcept C138885662 @default.
- W2026296040 hasConcept C150194340 @default.
- W2026296040 hasConcept C153911025 @default.
- W2026296040 hasConcept C161733203 @default.
- W2026296040 hasConcept C179926584 @default.
- W2026296040 hasConcept C185592680 @default.
- W2026296040 hasConcept C41895202 @default.
- W2026296040 hasConcept C54009773 @default.
- W2026296040 hasConcept C54355233 @default.
- W2026296040 hasConcept C86803240 @default.
- W2026296040 hasConcept C95444343 @default.
- W2026296040 hasConceptScore W2026296040C101762097 @default.
- W2026296040 hasConceptScore W2026296040C104317684 @default.
- W2026296040 hasConceptScore W2026296040C105580179 @default.
- W2026296040 hasConceptScore W2026296040C111335760 @default.
- W2026296040 hasConceptScore W2026296040C138885662 @default.
- W2026296040 hasConceptScore W2026296040C150194340 @default.
- W2026296040 hasConceptScore W2026296040C153911025 @default.
- W2026296040 hasConceptScore W2026296040C161733203 @default.
- W2026296040 hasConceptScore W2026296040C179926584 @default.
- W2026296040 hasConceptScore W2026296040C185592680 @default.
- W2026296040 hasConceptScore W2026296040C41895202 @default.
- W2026296040 hasConceptScore W2026296040C54009773 @default.
- W2026296040 hasConceptScore W2026296040C54355233 @default.
- W2026296040 hasConceptScore W2026296040C86803240 @default.
- W2026296040 hasConceptScore W2026296040C95444343 @default.
- W2026296040 hasIssue "3" @default.
- W2026296040 hasLocation W20262960401 @default.
- W2026296040 hasLocation W20262960402 @default.
- W2026296040 hasOpenAccess W2026296040 @default.
- W2026296040 hasPrimaryLocation W20262960401 @default.
- W2026296040 hasRelatedWork W1840763667 @default.
- W2026296040 hasRelatedWork W2043622035 @default.
- W2026296040 hasRelatedWork W2045115548 @default.
- W2026296040 hasRelatedWork W2082926700 @default.