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- W2026319932 abstract "Abstract The sleeping time of mice, injected intravenously with hexobarbital, increases linearly with the logarithm of the dose. The logarithm of the hexobarbital levels in mouse-brain decreases linearly with time from the 10th minute after an intravenous injection, indicating that from that time on the elimination of hexobarbital from brain is determined predominantly by the rate of its metabolism. It is therefore unlikely that in mice the accumulation of hexobarbital in fat is important in determining the duration of anesthesia. The hypothesis that the slope of a log dose-sleeping time line is equal to the first order rate constant for the elimination of hexobarbital from brain is invalid, because the elimination rate decreases with increasing dose." @default.
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- W2026319932 title "Pharmacokinetics and dose-sleeping time lines of hexobarbital in mice" @default.
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- W2026319932 doi "https://doi.org/10.1016/0014-2999(68)90137-4" @default.
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