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- W2026320121 abstract "This study aimed to characterize the clinicopathological features and prognosis of early onset gastric carcinomas (EOGCs) in a sample of young Portuguese adults.A subset of 415 patients submitted to gastric resection was divided into 2 groups: A--patients aged 45 years or less (n = 108), and B--patients older than 45 years (n = 307). The groups were compared for several clinicopathological features and the survival of the patients was analyzed by uni- and multivariate analysis.The surgical resection rate was higher in young patients, in whom tumors more frequently displayed an ulcerative shape (p < 0.001) and diffuse/isolated cell-type histology (p < 0.001). In the elderly, the rate of vascular invasion was significantly higher (p = 0.002). Overall, the survival of young patients was higher than in the elderly (p < 0.001). Survival curves were higher in young patients, except for pT4 and pM1 cases. In the multivariate survival analysis, age (p < 0.001), depth of tumor invasion (p < 0.001), nodal status (p < 0.001), vascular invasion (p = 0.011) and distant metastases (p = 0.007) emerged as independent prognostic factors for gastric carcinoma.Young gastric cancer patients no longer present with more advanced disease than the elderly and, overall, survival is better in young patients." @default.
- W2026320121 created "2016-06-24" @default.
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- W2026320121 date "2009-01-01" @default.
- W2026320121 modified "2023-10-13" @default.
- W2026320121 title "Early Onset Gastric Cancer No Longer Presents as an Advanced Disease with Ominous Prognosis" @default.
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- W2026320121 doi "https://doi.org/10.1159/000219331" @default.
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