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- W2026324043 abstract "Recent studies have demonstrated that granule cells in rat cerebellar slices exhibit a tonic form of GABAergic inhibition. The presence of a similar constitutive GABAergic conductance was investigated in synaptically coupled cultures of neonatal rat cerebellum. In cells exhibiting spontaneous inhibitory postsynaptic currents (IPSCs), application of the GABAA receptor antagonist bicuculline (10 μM) eliminated the IPSCs and also produced a significant decrease in holding current. This latter effect was lacking in cells that did not exhibit IPSCs. Application of TTX (1 μM) and Cd2+ (100 μM) decreased the IPSC frequency and also produced a change in holding current; these effects were eliminated by the prior application of bicuculline. In the presence of TTX, application of the benzodiazepine (BDZ) Flunitrazepam (1 μM) caused a 85±15% increase in the component of holding current that arose from GABAA receptor activity. Noise analysis indicated that the GABAA receptors underlying this tonic form of GABAergic inhibition exhibited a mean single channel conductance close to 14 pS, a value similar to that seen for somatic GABAA receptors in these cells. Thus, like their counterparts in cerebellar slices, cerebellar granule cells in culture exhibit a background GABAergic conductance. The most likely source of this tonic current is GABA spilt over from active inhibitory synapses. As this conductance was sensitive to benzodiazepine receptor agonists it is unlikely to arise entirely from GABAA receptors containing the α6 subunit." @default.
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- W2026324043 date "2000-05-01" @default.
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- W2026324043 title "Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells" @default.
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- W2026324043 doi "https://doi.org/10.1016/s0028-3908(99)00177-x" @default.
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