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• W2026326712 abstract "Se realiza un estudio descriptivo de las pacientes con diagnóstico de tumor mülleriano mixto maligno (TMMM) en términos de epidemiología, diagnóstico, tratamiento, seguimiento, recurrencias y supervivencia. Se revisaron los archivos anatomopatológicos y las historias médicas de las pacientes tratadas durante el período 1.990-2.006. Las supervivencias se analizan mediante las curvas de Kaplan-Meier. Se emplea un análisis de regresión logística en el estudio uni y multivariable. 43 pacientes son incluidas en esta revisión. El tratamiento inicial fue quirúrgico en el 79% de los casos. El 34,9% de las pacientes se diagnosticaron en estadio I; 16,3% en estadio II; 34,9% en estadio III y 9,3% en estadio IV. Se alcanzó una respuesta completa en el 60,4%. La enfermedad persistió en el 39,6%. La supervivencia libre de enfermedad a los 2, 5 y 10 años fue del 50%, con una mediana de 15 meses (IC 95% 6-32). La tasa de recurrencia fue del 42,3% con un tiempo medio de 8,4 meses. La supervivencia total a los 2, 5 y 10 años fue del 26% con una mediana de 7 meses (IC 95% 1-44). En el análisis univariante el tamaño tumoral, la invasión linfovascular, el estadio y la radioterapia pélvica adyuvante son factores pronósticos. En el análisis multivariante la invasión linfovascular, el estadio y la radioterapia son factores pronósticos independientes. Los TMMM son tumores de comportamiento clínico extremadamente agresivo con un pronóstico pobre. Los factores pronósticos que afectan la supervivencia son el estadio, la invasión linfovascular y la radioterapia pélvica. Malignant mixed Müllerian tumours (MMMT) patients were retrospectively evaluated in terms of epidemiology, diagnosis, treatment, follow-up, recurrent disease and survival. Medical and histopathology records were reviewed during the 17-year period 1990-2006. Survival rates were analysed by means of the Kaplan-Meier technique. The Cox proportional hazards regression model was used in uni- and multivariate analysis. A total of 43 patients were included in this study. First-line treatment was surgery in 79% of cases. Stage I, II, III and IV were identified in 34.9%, 16.3%, 34.9% and 9.3%, respectively. A complete response was achieved in 60.4% of patients. The disease was progressive in 39.6%. Event–free survival at 2, 5 and 10 years was 50% for all, with a median time of 15 months (95% CI,6-32). There was a 42.3% recurrence-rate with a mean time to recurrence of 8.4 months. The 2, 5 and 10-years overall survival was 26% with a median time of 7 months (95% CI, 1-44). In the univariate analysis tumour size, lymphovascular infiltration, stage and pelvic radiotherapy are prognostic factors. In the multivariate analysis lymphovascular infiltration, stage and radiotherapy were found to have an independent influence on overall survival. MMMT are tumours of aggressive clinical behaviour with a poor prognosis. Stage, lymphovascular infiltration and adjuvant radiotherapy are the dominant prognostic factors." @default.
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• W2026326712 date "2010-01-01" @default.
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• W2026326712 title "Tumor mülleriano mixto maligno: la experiencia de un único centro con 43 casos de 1990-2006" @default.
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