Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026331106> ?p ?o ?g. }
- W2026331106 endingPage "e73377" @default.
- W2026331106 startingPage "e73377" @default.
- W2026331106 abstract "In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions." @default.
- W2026331106 created "2016-06-24" @default.
- W2026331106 creator A5004835193 @default.
- W2026331106 creator A5023566325 @default.
- W2026331106 creator A5024435882 @default.
- W2026331106 creator A5026837899 @default.
- W2026331106 creator A5028197500 @default.
- W2026331106 creator A5030504800 @default.
- W2026331106 creator A5032314124 @default.
- W2026331106 creator A5048995643 @default.
- W2026331106 creator A5061728339 @default.
- W2026331106 creator A5063630764 @default.
- W2026331106 creator A5073976995 @default.
- W2026331106 creator A5077392976 @default.
- W2026331106 date "2013-11-06" @default.
- W2026331106 modified "2023-10-14" @default.
- W2026331106 title "Quantitative Analysis of PiB-PET with FreeSurfer ROIs" @default.
- W2026331106 cites W1540637463 @default.
- W2026331106 cites W1562548864 @default.
- W2026331106 cites W1964793333 @default.
- W2026331106 cites W1967642097 @default.
- W2026331106 cites W1969713959 @default.
- W2026331106 cites W1973365920 @default.
- W2026331106 cites W1974588580 @default.
- W2026331106 cites W1977714477 @default.
- W2026331106 cites W1985945455 @default.
- W2026331106 cites W1990143520 @default.
- W2026331106 cites W1991952617 @default.
- W2026331106 cites W2003428745 @default.
- W2026331106 cites W2004293194 @default.
- W2026331106 cites W2005483591 @default.
- W2026331106 cites W2012076586 @default.
- W2026331106 cites W2014897304 @default.
- W2026331106 cites W2025767301 @default.
- W2026331106 cites W2031489026 @default.
- W2026331106 cites W2034761873 @default.
- W2026331106 cites W2040434160 @default.
- W2026331106 cites W2040647120 @default.
- W2026331106 cites W2046613542 @default.
- W2026331106 cites W2046638602 @default.
- W2026331106 cites W2054929374 @default.
- W2026331106 cites W2063017390 @default.
- W2026331106 cites W2075348467 @default.
- W2026331106 cites W2079225922 @default.
- W2026331106 cites W2088594729 @default.
- W2026331106 cites W2089632738 @default.
- W2026331106 cites W2096410114 @default.
- W2026331106 cites W2101135654 @default.
- W2026331106 cites W2102099319 @default.
- W2026331106 cites W2111399612 @default.
- W2026331106 cites W2122320288 @default.
- W2026331106 cites W2133719476 @default.
- W2026331106 cites W2134721386 @default.
- W2026331106 cites W2146146069 @default.
- W2026331106 cites W2148079076 @default.
- W2026331106 cites W2151130155 @default.
- W2026331106 cites W2154067471 @default.
- W2026331106 cites W2156754774 @default.
- W2026331106 cites W2157885417 @default.
- W2026331106 cites W2160597466 @default.
- W2026331106 cites W2166406463 @default.
- W2026331106 cites W2167720733 @default.
- W2026331106 cites W2171346860 @default.
- W2026331106 doi "https://doi.org/10.1371/journal.pone.0073377" @default.
- W2026331106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3819320" @default.
- W2026331106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24223109" @default.
- W2026331106 hasPublicationYear "2013" @default.
- W2026331106 type Work @default.
- W2026331106 sameAs 2026331106 @default.
- W2026331106 citedByCount "172" @default.
- W2026331106 countsByYear W20263311062014 @default.
- W2026331106 countsByYear W20263311062015 @default.
- W2026331106 countsByYear W20263311062016 @default.
- W2026331106 countsByYear W20263311062017 @default.
- W2026331106 countsByYear W20263311062018 @default.
- W2026331106 countsByYear W20263311062019 @default.
- W2026331106 countsByYear W20263311062020 @default.
- W2026331106 countsByYear W20263311062021 @default.
- W2026331106 countsByYear W20263311062022 @default.
- W2026331106 countsByYear W20263311062023 @default.
- W2026331106 crossrefType "journal-article" @default.
- W2026331106 hasAuthorship W2026331106A5004835193 @default.
- W2026331106 hasAuthorship W2026331106A5023566325 @default.
- W2026331106 hasAuthorship W2026331106A5024435882 @default.
- W2026331106 hasAuthorship W2026331106A5026837899 @default.
- W2026331106 hasAuthorship W2026331106A5028197500 @default.
- W2026331106 hasAuthorship W2026331106A5030504800 @default.
- W2026331106 hasAuthorship W2026331106A5032314124 @default.
- W2026331106 hasAuthorship W2026331106A5048995643 @default.
- W2026331106 hasAuthorship W2026331106A5061728339 @default.
- W2026331106 hasAuthorship W2026331106A5063630764 @default.
- W2026331106 hasAuthorship W2026331106A5073976995 @default.
- W2026331106 hasAuthorship W2026331106A5077392976 @default.
- W2026331106 hasBestOaLocation W20263311061 @default.
- W2026331106 hasConcept C104709138 @default.
- W2026331106 hasConcept C126838900 @default.
- W2026331106 hasConcept C142724271 @default.
- W2026331106 hasConcept C143409427 @default.