Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026346411> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2026346411 abstract "Objective: To review the use of belatacept as an alternative to calcineurin inhibitor-based regimens for maintenance immunosuppression in renal transplant recipients. Data Sources: To provide an extensive overview of the pharmacology, pharmacokinetics, efficacy, and safety of belatacept, a MEDLINE/PubMed search (1980–December 2011) was performed for all articles evaluating belatacept's properties and patient outcomes, as well as abstracts from recent meetings, using key words belatacept, pharmacology, efficacy, pharmacokinetics, and safety. Study Selection/Data Extraction: Phase 2 and 3 studies in humans describing use, adverse reactions, pharmacology, pharmacokinetics, efficacy, and safety of belatacept were identified and reviewed. Other articles were identified through PubMed. Data Synthesis: Belatacept, a costimulation blocker, is a biologic recombinant fusion protein that has been shown to prevent acute cellular rejection in kidney transplant recipients and preserve renal function. It was recently approved by the FDA as an antirejection immunosuppressant agent for use in kidney transplant recipients. It is the first biologic agent used for maintenance immunosuppression. It acts as an antagonist to CD80 and CD86 receptors located on the surface of antigen presenting cells, thereby blocking CD28 T-cell activation and, thus, preventing acute rejection. In comparison with patients receiving other current therapies, patients on belatacept have demonstrated superior renal function with comparable outcomes in patient and graft survival. Conclusions: Belatacept has potential for use as an alternative to current maintenance immunosuppression regimens, with potentially fewer adverse effects." @default.
- W2026346411 created "2016-06-24" @default.
- W2026346411 creator A5025981666 @default.
- W2026346411 creator A5039230603 @default.
- W2026346411 creator A5077535330 @default.
- W2026346411 creator A5089616616 @default.
- W2026346411 date "2012-05-01" @default.
- W2026346411 modified "2023-09-26" @default.
- W2026346411 title "Belatacept Post Kidney Transplantation" @default.
- W2026346411 cites W1862437987 @default.
- W2026346411 cites W1971245044 @default.
- W2026346411 cites W1973505502 @default.
- W2026346411 cites W1976722591 @default.
- W2026346411 cites W1989082515 @default.
- W2026346411 cites W1994969460 @default.
- W2026346411 cites W2006625022 @default.
- W2026346411 cites W2013659324 @default.
- W2026346411 cites W2022531506 @default.
- W2026346411 cites W2037626742 @default.
- W2026346411 cites W2040318571 @default.
- W2026346411 cites W2043309772 @default.
- W2026346411 cites W2062443745 @default.
- W2026346411 cites W2077684987 @default.
- W2026346411 cites W2081200574 @default.
- W2026346411 cites W2096103932 @default.
- W2026346411 cites W2097211609 @default.
- W2026346411 cites W2107346812 @default.
- W2026346411 cites W2117053752 @default.
- W2026346411 cites W2117095174 @default.
- W2026346411 cites W2130168880 @default.
- W2026346411 cites W2137780217 @default.
- W2026346411 cites W2147688731 @default.
- W2026346411 cites W2153602317 @default.
- W2026346411 cites W2333679166 @default.
- W2026346411 cites W4255496125 @default.
- W2026346411 doi "https://doi.org/10.1177/875512251202800304" @default.
- W2026346411 hasPublicationYear "2012" @default.
- W2026346411 type Work @default.
- W2026346411 sameAs 2026346411 @default.
- W2026346411 citedByCount "0" @default.
- W2026346411 crossrefType "journal-article" @default.
- W2026346411 hasAuthorship W2026346411A5025981666 @default.
- W2026346411 hasAuthorship W2026346411A5039230603 @default.
- W2026346411 hasAuthorship W2026346411A5077535330 @default.
- W2026346411 hasAuthorship W2026346411A5089616616 @default.
- W2026346411 hasConcept C126322002 @default.
- W2026346411 hasConcept C177713679 @default.
- W2026346411 hasConcept C203014093 @default.
- W2026346411 hasConcept C2780303639 @default.
- W2026346411 hasConcept C2780743877 @default.
- W2026346411 hasConcept C2911091166 @default.
- W2026346411 hasConcept C2994498544 @default.
- W2026346411 hasConcept C71924100 @default.
- W2026346411 hasConceptScore W2026346411C126322002 @default.
- W2026346411 hasConceptScore W2026346411C177713679 @default.
- W2026346411 hasConceptScore W2026346411C203014093 @default.
- W2026346411 hasConceptScore W2026346411C2780303639 @default.
- W2026346411 hasConceptScore W2026346411C2780743877 @default.
- W2026346411 hasConceptScore W2026346411C2911091166 @default.
- W2026346411 hasConceptScore W2026346411C2994498544 @default.
- W2026346411 hasConceptScore W2026346411C71924100 @default.
- W2026346411 hasLocation W20263464111 @default.
- W2026346411 hasOpenAccess W2026346411 @default.
- W2026346411 hasPrimaryLocation W20263464111 @default.
- W2026346411 hasRelatedWork W2108444491 @default.
- W2026346411 hasRelatedWork W2157403254 @default.
- W2026346411 hasRelatedWork W2164970529 @default.
- W2026346411 hasRelatedWork W2217404098 @default.
- W2026346411 hasRelatedWork W2333284666 @default.
- W2026346411 hasRelatedWork W2406877319 @default.
- W2026346411 hasRelatedWork W2410223788 @default.
- W2026346411 hasRelatedWork W2428023230 @default.
- W2026346411 hasRelatedWork W2599834397 @default.
- W2026346411 hasRelatedWork W2617078979 @default.
- W2026346411 hasRelatedWork W2741902829 @default.
- W2026346411 hasRelatedWork W2773519813 @default.
- W2026346411 hasRelatedWork W2804790358 @default.
- W2026346411 hasRelatedWork W2890235241 @default.
- W2026346411 hasRelatedWork W2907734199 @default.
- W2026346411 hasRelatedWork W3041466182 @default.
- W2026346411 hasRelatedWork W3096582261 @default.
- W2026346411 hasRelatedWork W3209235410 @default.
- W2026346411 hasRelatedWork W3212873929 @default.
- W2026346411 hasRelatedWork W2938391300 @default.
- W2026346411 isParatext "false" @default.
- W2026346411 isRetracted "false" @default.
- W2026346411 magId "2026346411" @default.
- W2026346411 workType "article" @default.