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- W2026347788 endingPage "e1003048" @default.
- W2026347788 startingPage "e1003048" @default.
- W2026347788 abstract "Heat-shock protein 90 (Hsp90) inhibitors exhibit activity against human cancers. We evaluated a series of new, oral bioavailable, chemically diverse Hsp90 inhibitors (PU-H71, AUY922, BIIB021, NVP-BEP800) against Kaposi sarcoma (KS). All Hsp90 inhibitors exhibited nanomolar EC(50) in culture and AUY922 reduced tumor burden in a xenograft model of KS. KS is associated with KS-associated herpesvirus (KSHV). We identified the viral latency associated nuclear antigen (LANA) as a novel client protein of Hsp90 and demonstrate that the Hsp90 inhibitors diminish the level of LANA through proteasomal degradation. These Hsp90 inhibitors also downregulated EphA2 and ephrin-B2 protein levels. LANA is essential for viral maintenance and EphA2 has recently been shown to facilitate KSHV infection; which in turn feeds latent persistence. Further, both molecules are required for KS tumor formation and both were downregulated in response to Hsp90 inhibitors. This provides a rationale for clinical testing of Hsp90 inhibitors in KSHV-associated cancers and in the eradication of latent KSHV reservoirs." @default.
- W2026347788 created "2016-06-24" @default.
- W2026347788 creator A5004670954 @default.
- W2026347788 creator A5021245679 @default.
- W2026347788 creator A5041987464 @default.
- W2026347788 creator A5068663202 @default.
- W2026347788 creator A5073057265 @default.
- W2026347788 date "2012-11-29" @default.
- W2026347788 modified "2023-09-23" @default.
- W2026347788 title "Hsp90 Inhibitors Are Efficacious against Kaposi Sarcoma by Enhancing the Degradation of the Essential Viral Gene LANA, of the Viral Co-Receptor EphA2 as well as Other Client Proteins" @default.
- W2026347788 cites W1523189699 @default.
- W2026347788 cites W1673837423 @default.
- W2026347788 cites W1963854942 @default.
- W2026347788 cites W1965224337 @default.
- W2026347788 cites W1968916175 @default.
- W2026347788 cites W1972331061 @default.
- W2026347788 cites W1974756622 @default.
- W2026347788 cites W1977500292 @default.
- W2026347788 cites W1980819464 @default.
- W2026347788 cites W1982343053 @default.
- W2026347788 cites W1982470962 @default.
- W2026347788 cites W1989600727 @default.
- W2026347788 cites W1990660755 @default.
- W2026347788 cites W1993105675 @default.
- W2026347788 cites W1993525477 @default.
- W2026347788 cites W1995782808 @default.
- W2026347788 cites W1997670728 @default.
- W2026347788 cites W1998556995 @default.
- W2026347788 cites W1999715990 @default.
- W2026347788 cites W2005157049 @default.
- W2026347788 cites W2009584325 @default.
- W2026347788 cites W2009714338 @default.
- W2026347788 cites W2011818870 @default.
- W2026347788 cites W2015779295 @default.
- W2026347788 cites W2017519742 @default.
- W2026347788 cites W2018138792 @default.
- W2026347788 cites W2019310947 @default.
- W2026347788 cites W2019745410 @default.
- W2026347788 cites W2019817592 @default.
- W2026347788 cites W2021522625 @default.
- W2026347788 cites W2021593763 @default.
- W2026347788 cites W2021970375 @default.
- W2026347788 cites W2022531767 @default.
- W2026347788 cites W2028978816 @default.
- W2026347788 cites W2029431941 @default.
- W2026347788 cites W2031358406 @default.
- W2026347788 cites W2032130254 @default.
- W2026347788 cites W2037720741 @default.
- W2026347788 cites W2040688801 @default.
- W2026347788 cites W2047338936 @default.
- W2026347788 cites W2053543225 @default.
- W2026347788 cites W2054485871 @default.
- W2026347788 cites W2054861724 @default.
- W2026347788 cites W2056693633 @default.
- W2026347788 cites W2060902443 @default.
- W2026347788 cites W2063956958 @default.
- W2026347788 cites W2065704346 @default.
- W2026347788 cites W2066410692 @default.
- W2026347788 cites W2071146908 @default.
- W2026347788 cites W2085622884 @default.
- W2026347788 cites W2088814252 @default.
- W2026347788 cites W2093318486 @default.
- W2026347788 cites W2094736151 @default.
- W2026347788 cites W2099904968 @default.
- W2026347788 cites W2100768063 @default.
- W2026347788 cites W2102030590 @default.
- W2026347788 cites W2103618960 @default.
- W2026347788 cites W2105821529 @default.
- W2026347788 cites W2107942125 @default.
- W2026347788 cites W2110599787 @default.
- W2026347788 cites W2112133866 @default.
- W2026347788 cites W2112875738 @default.
- W2026347788 cites W2113694619 @default.
- W2026347788 cites W2115527176 @default.
- W2026347788 cites W2118444588 @default.
- W2026347788 cites W2121508665 @default.
- W2026347788 cites W2121702161 @default.
- W2026347788 cites W2121964400 @default.
- W2026347788 cites W2122584651 @default.
- W2026347788 cites W2123486053 @default.
- W2026347788 cites W2129271918 @default.
- W2026347788 cites W2129377621 @default.
- W2026347788 cites W2131384028 @default.
- W2026347788 cites W2132919995 @default.
- W2026347788 cites W2133082612 @default.
- W2026347788 cites W2134376592 @default.
- W2026347788 cites W2134870125 @default.
- W2026347788 cites W2141653723 @default.
- W2026347788 cites W2145298081 @default.
- W2026347788 cites W2146366919 @default.
- W2026347788 cites W2149744296 @default.
- W2026347788 cites W2157566255 @default.
- W2026347788 cites W2157774412 @default.
- W2026347788 cites W2158797202 @default.
- W2026347788 cites W2159462264 @default.
- W2026347788 cites W2166999544 @default.
- W2026347788 cites W4254613993 @default.
- W2026347788 doi "https://doi.org/10.1371/journal.ppat.1003048" @default.