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• W2026357837 endingPage "200" @default.
• W2026357837 startingPage "189" @default.
• W2026357837 abstract "Nuclear factor (NF) κB is a pleiotropic transcription factor that is ubiquitously expressed. After transplantation of solid organs, NF-κB in the graft is activated within a few hours as a consequence of ischemia/reperfusion and then again after a few days in intragraft infiltrating cells during the process of acute allograft rejection. In the present article, we review the components of the NF-κB pathway, their mechanisms of activation, and their role in T cell and antigen-presenting cell activation and differentiation and in solid organ allograft rejection. Targeted inhibition of NF-κB in selected cell types may promote graft survival with fewer adverse effects compared with global immunosuppressive therapies." @default.
• W2026357837 created "2016-06-24" @default.
• W2026357837 creator A5023053917 @default.
• W2026357837 creator A5056037326 @default.
• W2026357837 date "2012-07-01" @default.
• W2026357837 modified "2023-10-03" @default.
• W2026357837 title "Role of T cell–nuclear factor κB in transplantation" @default.
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