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- W2026360229 abstract "Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes associated with lipid metabolism. Recent studies have suggested that the expression of PPARalpha-dependent fibroblast growth factor 21 (FGF21) plays important roles in adaptation to fasting, such as lipolysis and ketogenesis. We found that a nighttime injection of bezafibrate, a ligand of PPARalpha, effectively induced FGF21 expression, whereas a daytime injection did not affect it. Furthermore, bezafibrate-induced circadian FGF21 expression was abolished in PPARalpha-deficient mice. These observations suggest that bezafibrate-induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARalpha system in the liver." @default.
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- W2026360229 date "2008-10-07" @default.
- W2026360229 modified "2023-10-16" @default.
- W2026360229 title "Circadian expression of<i>FGF21</i>is induced by PPARα activation in the mouse liver" @default.
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- W2026360229 doi "https://doi.org/10.1016/j.febslet.2008.09.046" @default.
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