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• W2026366861 abstract "ObjectiveOur study aimed to determine the influence of high P4 levels on clinical outcomes in high ovarian response.DesignRetrospective cohort study.Materials and MethodsWe performed a retrospective analysis of 2570 cycles (January 2009-December 2012) comparing high (P4>1.5 ng/ml) or low (P4<1.5 ng/ml) progesterone levels in patients undergoing controlled stimulation and classified as high responders (E2>3000 pg/ml on the hCG day). Patients were stimulated with daily doses of 100-150 UI of recombinant FSH (Puregon®, MSD) starting on day 2-3; GnRH antagonist was added when the leading follicle reached a diameter of 14 mm (Cetrotide, 0.25 mg/day, Merck-Serono) and a single bolus of 250 μg of rhCG (Ovitrelle, Merck-Serono) was administered to induce oocyte maturation. Chi-squared test and ANOVA were applied to detect statistical differences; p<0.05 was considered statistically significant.ResultsRegarding the influence of progesterone concentration on clinical outcomes in presence of high estradiol levels, we did not find significant differences in any of the clinical variables analyzed. However, we observed statistical differences in E2 and P4 levels on the day of hCG between the two groups of the study.ConclusionOur data suggest that in high responder women with estradiol levels over 3000 pg/ml, progesterone levels do not affect IVF results. We confirmed the close link between E2 and P4 as we observed that high E2 levels are significant correlated with high P4 levels. These results lead us to conclude that, regardless the progesterone levels attached during the cycle in high responders, clinical outcomes are not affected. ObjectiveOur study aimed to determine the influence of high P4 levels on clinical outcomes in high ovarian response. Our study aimed to determine the influence of high P4 levels on clinical outcomes in high ovarian response. DesignRetrospective cohort study. Retrospective cohort study. Materials and MethodsWe performed a retrospective analysis of 2570 cycles (January 2009-December 2012) comparing high (P4>1.5 ng/ml) or low (P4<1.5 ng/ml) progesterone levels in patients undergoing controlled stimulation and classified as high responders (E2>3000 pg/ml on the hCG day). Patients were stimulated with daily doses of 100-150 UI of recombinant FSH (Puregon®, MSD) starting on day 2-3; GnRH antagonist was added when the leading follicle reached a diameter of 14 mm (Cetrotide, 0.25 mg/day, Merck-Serono) and a single bolus of 250 μg of rhCG (Ovitrelle, Merck-Serono) was administered to induce oocyte maturation. Chi-squared test and ANOVA were applied to detect statistical differences; p<0.05 was considered statistically significant. We performed a retrospective analysis of 2570 cycles (January 2009-December 2012) comparing high (P4>1.5 ng/ml) or low (P4<1.5 ng/ml) progesterone levels in patients undergoing controlled stimulation and classified as high responders (E2>3000 pg/ml on the hCG day). Patients were stimulated with daily doses of 100-150 UI of recombinant FSH (Puregon®, MSD) starting on day 2-3; GnRH antagonist was added when the leading follicle reached a diameter of 14 mm (Cetrotide, 0.25 mg/day, Merck-Serono) and a single bolus of 250 μg of rhCG (Ovitrelle, Merck-Serono) was administered to induce oocyte maturation. Chi-squared test and ANOVA were applied to detect statistical differences; p<0.05 was considered statistically significant. ResultsRegarding the influence of progesterone concentration on clinical outcomes in presence of high estradiol levels, we did not find significant differences in any of the clinical variables analyzed. However, we observed statistical differences in E2 and P4 levels on the day of hCG between the two groups of the study. Regarding the influence of progesterone concentration on clinical outcomes in presence of high estradiol levels, we did not find significant differences in any of the clinical variables analyzed. However, we observed statistical differences in E2 and P4 levels on the day of hCG between the two groups of the study. ConclusionOur data suggest that in high responder women with estradiol levels over 3000 pg/ml, progesterone levels do not affect IVF results. We confirmed the close link between E2 and P4 as we observed that high E2 levels are significant correlated with high P4 levels. These results lead us to conclude that, regardless the progesterone levels attached during the cycle in high responders, clinical outcomes are not affected. Our data suggest that in high responder women with estradiol levels over 3000 pg/ml, progesterone levels do not affect IVF results. We confirmed the close link between E2 and P4 as we observed that high E2 levels are significant correlated with high P4 levels. These results lead us to conclude that, regardless the progesterone levels attached during the cycle in high responders, clinical outcomes are not affected." @default.
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• W2026366861 date "2013-09-01" @default.
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• W2026366861 title "High progesterone levels in high ovarian rsponse do not affect clinical outcomes" @default.
• W2026366861 doi "https://doi.org/10.1016/j.fertnstert.2013.07.1674" @default.
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