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- W2026374268 abstract "SAA5-O-06 Introduction: Ambient levels of air pollution have previously been observed in association with postneonatal infant mortality due to respiratory causes. We further investigated this hypothesis in 96 counties throughout the United States, including an assessment of confounding by maternal smoking status. Methods: Birth and infant death data for all U.S. births over the study period 1999 to 2002 were obtained and linked to particulate and gaseous air pollution monitoring data. Pollution exposure was calculated as the average county concentration during the first 2 months of the infant's life. The occurrence of respiratory postneonatal infant mortality was evaluated in relation to air pollution levels using generalized estimating equations, adjusting for maternal, temporal, and regional factors. Using the subset of birth records, which included maternal smoking status, we ran models with and without smoking to assess potential confounding by maternal smoking. In addition, we assessed the relationship between indices of air pollution and respiratory death after stratification by birthweight status: low birth weight (<2500 g) and normal birth weight (≥2500 g). Results: After linkage and exclusions, the study population consisted of 3.6 million births with 404 respiratory-related deaths in 96 counties. In single pollutant models, postneonatal respiratory death was associated with PM10 (per interquartile range increase OR = 1.16; 95% CI, 1.04–1.29), PM2.5 (OR = 1.05; 95% CI, 0.87–1.27), and CO (OR = 1.14; 95% CI, 0.93–1.39). The subset of birth records containing maternal smoking data included 2.5 million births, with 333 postneonatal respiratory deaths. Controlling for smoking in the model had no effect on the parameter estimates for any of the pollutants: PM2.5, CO, or PM10. When the study population was stratified by birth weight status, effect estimates for PM2.5, CO, and PM10 were elevated in both strata; however, the association was stronger for all pollutants in the normal birth weight stratum. In multipollutant models, only PM remained elevated and significant. Discussion: These findings support a relationship between particles and postneonatal infant respiratory death. Results suggest that effects may be stronger in normal birth weight infants; possible explanations for effect modification by birth weight will be discussed. This study provides no evidence that the relationship between county-level air pollution and postneonatal respiratory death is confounded by maternal smoking status. Views are of the authors and not of their institutions." @default.
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- W2026374268 date "2006-11-01" @default.
- W2026374268 modified "2023-09-26" @default.
- W2026374268 title "Ambient Air Pollution, Maternal Smoking, and Respiratory-Related Infant Mortality" @default.
- W2026374268 doi "https://doi.org/10.1097/00001648-200611001-00323" @default.
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