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- W2026379800 abstract "The present study utilized in vivo microdialysis to investigate the importance of 5-HT1A autoreceptors and α1-adrenoceptors in the decreased 5-HT release obtained following administration of the mixed 5-HT1A autoreceptor partial agonist/α1-adrenoceptors antagonist BMY7378, the selective 5-HT1A receptor agonist 8-OH-DPAT and the α1-adrenoceptors antagonist prazosin. BMY7378 (0.25 mg/kg, s.c.), 8-OH-DPAT (0.025 mg/kg, s.c.) and prazosin (0.1–1.0 mg/kg, s.c.) all suppressed ventral hippocampal 5-HT efflux. The BMY7378- and 8-OH-DPAT-induced inhibition of 5-HT release were reversed by a 40 min pre-treatment with either (±)pindolol (8 mg/kg, s.c.) or WAY-100635 (0.3 mg/kg, s.c.), to block 5-HT1A autoreceptors. Neither of these antagonists altered the prazosin-induced (0.3 mg/kg, s.c.) 5-HT decrease. The results: (i) confirm that both an α1-adrenoceptors antagonist (prazosin) and 5-HT1A autoreceptor stimulants (BMY7378 and 8-OH-DPAT) may reduce cerebral 5-HT release; (ii) support that the BMY7378-induced decrease in 5-HT release results from 5-HT1A autoreceptor agonism, rather than α1-adrenoceptors blockade; and (iii) argue against “physiological” antagonism (i.e. via blockade of β-adrenoceptors, 5-HT1B receptors or some other mechanism) as an explanation for the reversal by pindolol of 5-HT1A autoreceptor agonist-induced suppression of 5-HT release. These data support the usefulness of pindolol, as well as the more specific compound WAY-100635, to block 5-HT1A autoreceptors." @default.
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- W2026379800 date "1995-06-01" @default.
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- W2026379800 title "Studies on the role of 5-HT1A autoreceptors and α1-adrenoceptors in the inhibition of 5-HT release—I. BMY7378 and prazosin" @default.
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- W2026379800 doi "https://doi.org/10.1016/0028-3908(95)00038-8" @default.
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