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• W2026386906 abstract "Asthma, atopy, and related phenotypes are heterogeneous complex traits, with both genetic and environmental risk factors. Extensive research has been conducted and over hundred genes have been associated with asthma and atopy phenotypes, but many of these findings have failed to replicate in subsequent studies. To separate true associations from false positives, candidate genes need to be examined in large well-characterized samples, using standardized designs (genotyping, phenotyping and analysis). In an attempt to replicate previous associations we amalgamated the power and resources of four studies and genotyped 5,565 individuals to conduct a genetic association study of 93 previously associated candidate genes for asthma and related phenotypes using the same set of 861 single-nucleotide polymorphisms (SNPs), a common genotyping platform, and relatively harmonized phenotypes. We tested for association between SNPs and the dichotomous outcomes of asthma, atopy, atopic asthma, and airway hyperresponsiveness using a general allelic likelihood ratio test. No SNP in any gene reached significance levels that survived correction for all tested SNPs, phenotypes, and genes. Even after relaxing the usual stringent multiple testing corrections by performing a gene-based analysis (one gene at a time as if no other genes were typed) and by stratifying SNPs based on their prior evidence of association, no genes gave strong evidence of replication. There was weak evidence to implicate the following: IL13, IFNGR2, EDN1, and VDR in asthma; IL18, TBXA2R, IFNGR2, and VDR in atopy; TLR9, TBXA2R, VDR, NOD2, and STAT6 in airway hyperresponsiveness; TLR10, IFNGR2, STAT6, VDR, and NPSR1 in atopic asthma. Additionally we found an excess of SNPs with small effect sizes (OR < 1.4). The low rate of replication may be due to small effect size, differences in phenotypic definition, differential environmental effects, and/or genetic heterogeneity. To aid in future replication studies of asthma genes a comprehensive database was compiled and is available to the scientific community at http://genapha.icapture.ubc.ca/." @default.
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• W2026386906 date "2009-02-27" @default.
• W2026386906 modified "2023-10-17" @default.
• W2026386906 title "Analyses of associations with asthma in four asthma population samples from Canada and Australia" @default.
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• W2026386906 cites W1970546858 @default.
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• W2026386906 cites W1998183937 @default.
• W2026386906 cites W1998641738 @default.
• W2026386906 cites W1999058245 @default.
• W2026386906 cites W2008599922 @default.
• W2026386906 cites W2012734282 @default.
• W2026386906 cites W2029220352 @default.
• W2026386906 cites W2029337166 @default.
• W2026386906 cites W2030705868 @default.
• W2026386906 cites W2031273905 @default.
• W2026386906 cites W2033425349 @default.
• W2026386906 cites W2035604671 @default.
• W2026386906 cites W2042944593 @default.
• W2026386906 cites W2044019719 @default.
• W2026386906 cites W2044847356 @default.
• W2026386906 cites W2046423800 @default.
• W2026386906 cites W2047081723 @default.
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• W2026386906 cites W2057436414 @default.
• W2026386906 cites W2064795641 @default.
• W2026386906 cites W2074313486 @default.
• W2026386906 cites W2077016434 @default.
• W2026386906 cites W2090017080 @default.
• W2026386906 cites W2092296830 @default.
• W2026386906 cites W2096149081 @default.
• W2026386906 cites W2099601953 @default.
• W2026386906 cites W2100259422 @default.
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• W2026386906 cites W2135527487 @default.
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• W2026386906 cites W2147351691 @default.
• W2026386906 cites W2155605798 @default.
• W2026386906 cites W2155925153 @default.
• W2026386906 cites W2158188281 @default.
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• W2026386906 cites W2166226439 @default.
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• W2026386906 doi "https://doi.org/10.1007/s00439-009-0643-8" @default.
• W2026386906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19247692" @default.
• W2026386906 hasPublicationYear "2009" @default.
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