Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026388315> ?p ?o ?g. }
- W2026388315 endingPage "1347" @default.
- W2026388315 startingPage "1341" @default.
- W2026388315 abstract "Cigarette smoke is a risk factor for human health, and many studies were conducted to investigate its adverse effects on humans and other mammals. However, since large amounts of cigarette products are produced and consumed, it is possible that tobacco chemicals can end up in aquatic environments through several routes, thus influencing aquatic organisms. In this study, the presence of tobacco-specific nitrosamine (TSNA), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in aquatic environment was demonstrated. Since toxic effects on and distribution patterns of tobacco chemicals in aquatic organisms were rarely studied, after results of an acute toxicity pretest were obtained, experiment was conducted to investigate the bioaccumulation pattern of NNK and distribution patterns of its metabolites, mainly 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), in NNK-treated freshwater planarians, Dugesia japonica. Results from in vivo and in vitro studies showed that NNK was readily converted to NNAL through the carbonyl reduction in bodies of NNK-treated planarians. Tissue concentrations of both chemicals increased in time- and dose-dependent manners. Furthermore, we examined the end products of NNK/NNAL α-hydroxylation in NNK-treated planarians, but only 1-(3-pyridyl)-1,4-butanediol was detected, suggesting that NNK metabolism in planarians partially differs from that in mammalian systems. This is the first report on NNK metabolism in an aquatic organism and can be used as a foundation for developing freshwater planarians as a new in vivo model for the study of NNK toxicology in the future." @default.
- W2026388315 created "2016-06-24" @default.
- W2026388315 creator A5001293161 @default.
- W2026388315 creator A5016298087 @default.
- W2026388315 creator A5022551520 @default.
- W2026388315 creator A5082405889 @default.
- W2026388315 date "2012-06-01" @default.
- W2026388315 modified "2023-10-17" @default.
- W2026388315 title "In vivo and in vitro metabolism of tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by the freshwater planarian, Dugesia japonica" @default.
- W2026388315 cites W1979196212 @default.
- W2026388315 cites W1984060519 @default.
- W2026388315 cites W1992351398 @default.
- W2026388315 cites W1997828131 @default.
- W2026388315 cites W1998488814 @default.
- W2026388315 cites W2008784198 @default.
- W2026388315 cites W2010990416 @default.
- W2026388315 cites W2011604491 @default.
- W2026388315 cites W2016469373 @default.
- W2026388315 cites W2022677660 @default.
- W2026388315 cites W2023476760 @default.
- W2026388315 cites W2026641296 @default.
- W2026388315 cites W2043453859 @default.
- W2026388315 cites W2044943027 @default.
- W2026388315 cites W2051899214 @default.
- W2026388315 cites W2053173597 @default.
- W2026388315 cites W2070611230 @default.
- W2026388315 cites W2072879324 @default.
- W2026388315 cites W2083413894 @default.
- W2026388315 cites W2093287090 @default.
- W2026388315 cites W2093339780 @default.
- W2026388315 cites W2093616637 @default.
- W2026388315 cites W2101324933 @default.
- W2026388315 cites W2104241203 @default.
- W2026388315 cites W2118416526 @default.
- W2026388315 cites W2122975754 @default.
- W2026388315 cites W2127294029 @default.
- W2026388315 cites W2131359370 @default.
- W2026388315 cites W2158576288 @default.
- W2026388315 cites W2171924267 @default.
- W2026388315 cites W4240519790 @default.
- W2026388315 doi "https://doi.org/10.1016/j.chemosphere.2012.02.024" @default.
- W2026388315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22386463" @default.
- W2026388315 hasPublicationYear "2012" @default.
- W2026388315 type Work @default.
- W2026388315 sameAs 2026388315 @default.
- W2026388315 citedByCount "9" @default.
- W2026388315 countsByYear W20263883152013 @default.
- W2026388315 countsByYear W20263883152014 @default.
- W2026388315 countsByYear W20263883152016 @default.
- W2026388315 countsByYear W20263883152018 @default.
- W2026388315 countsByYear W20263883152021 @default.
- W2026388315 countsByYear W20263883152022 @default.
- W2026388315 crossrefType "journal-article" @default.
- W2026388315 hasAuthorship W2026388315A5001293161 @default.
- W2026388315 hasAuthorship W2026388315A5016298087 @default.
- W2026388315 hasAuthorship W2026388315A5022551520 @default.
- W2026388315 hasAuthorship W2026388315A5082405889 @default.
- W2026388315 hasBestOaLocation W20263883152 @default.
- W2026388315 hasConcept C107872376 @default.
- W2026388315 hasConcept C114246631 @default.
- W2026388315 hasConcept C150903083 @default.
- W2026388315 hasConcept C171056886 @default.
- W2026388315 hasConcept C178790620 @default.
- W2026388315 hasConcept C181199279 @default.
- W2026388315 hasConcept C185592680 @default.
- W2026388315 hasConcept C207001950 @default.
- W2026388315 hasConcept C2775935104 @default.
- W2026388315 hasConcept C2777395278 @default.
- W2026388315 hasConcept C27881333 @default.
- W2026388315 hasConcept C29730261 @default.
- W2026388315 hasConcept C33070731 @default.
- W2026388315 hasConcept C55493867 @default.
- W2026388315 hasConcept C62231903 @default.
- W2026388315 hasConcept C71572567 @default.
- W2026388315 hasConcept C8381438 @default.
- W2026388315 hasConcept C86803240 @default.
- W2026388315 hasConcept C95444343 @default.
- W2026388315 hasConcept C98274493 @default.
- W2026388315 hasConceptScore W2026388315C107872376 @default.
- W2026388315 hasConceptScore W2026388315C114246631 @default.
- W2026388315 hasConceptScore W2026388315C150903083 @default.
- W2026388315 hasConceptScore W2026388315C171056886 @default.
- W2026388315 hasConceptScore W2026388315C178790620 @default.
- W2026388315 hasConceptScore W2026388315C181199279 @default.
- W2026388315 hasConceptScore W2026388315C185592680 @default.
- W2026388315 hasConceptScore W2026388315C207001950 @default.
- W2026388315 hasConceptScore W2026388315C2775935104 @default.
- W2026388315 hasConceptScore W2026388315C2777395278 @default.
- W2026388315 hasConceptScore W2026388315C27881333 @default.
- W2026388315 hasConceptScore W2026388315C29730261 @default.
- W2026388315 hasConceptScore W2026388315C33070731 @default.
- W2026388315 hasConceptScore W2026388315C55493867 @default.
- W2026388315 hasConceptScore W2026388315C62231903 @default.
- W2026388315 hasConceptScore W2026388315C71572567 @default.
- W2026388315 hasConceptScore W2026388315C8381438 @default.
- W2026388315 hasConceptScore W2026388315C86803240 @default.
- W2026388315 hasConceptScore W2026388315C95444343 @default.
- W2026388315 hasConceptScore W2026388315C98274493 @default.