FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026395409> ?p ?o ?g. }

• W2026395409 abstract "You have accessJournal of UrologyBladder Cancer: Staging1 Apr 2015PD41-06 CLINICAL VALUE OF IMMUNOHISTOCHEMICALLY DETECTED LYMPHOVASCULAR INVASION IN TRANSURETHRAL BLADDER TUMOR RESECTION SPECIMEN FOR BLADDER CANCER STAGING BEFORE RADICAL CYSTECTOMY Tatsuo Gondo, Jun Nakashima, Rie Inoue, Takeshi Hashimoto, Yoshio Ohno, Makoto Ohori, Toshitaka Nagao, and Masaaki Tachibana Tatsuo GondoTatsuo Gondo More articles by this author , Jun NakashimaJun Nakashima More articles by this author , Rie InoueRie Inoue More articles by this author , Takeshi HashimotoTakeshi Hashimoto More articles by this author , Yoshio OhnoYoshio Ohno More articles by this author , Makoto OhoriMakoto Ohori More articles by this author , Toshitaka NagaoToshitaka Nagao More articles by this author , and Masaaki TachibanaMasaaki Tachibana More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2414AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It is one of our major concerns to investigate the clinical implication of lymphovascular invasion (LVI) in transurethral resection of bladder tumor (TURBT) specimens (TUR-LVI) in clinical decision making in patients with bladder cancer. Immunohistochemistry (IHC) may improve LVI detection in small TUR specimens. We aimed to investigate the clinical significance of TUR-LVI for bladder cancer staging and compare the clinical values of IHC-detected LVI (IHC-LVI) with HE-detected LVI (HE-LVI). METHODS This study included 157 non-metastatic bladder cancer patients treated with radical cystectomy (RC) at our institution. A single pathologist with expertise in genitourinary malignancies evaluated all TURBT specimens and assessed the venous, lymphatic and lymphovascular invasions in HE and IHC stained specimens. Two IHC markers for lymphatic channels (D2-40) and endothelial cells (CD31) were used to clarify lymphatic (ly) and venous (v) invasions in IHC studies. The univariate and multivariate logistic regression analyses were used to identify preoperative factors correlated with extra-vesical disease (≥pT3) at RC.□ RESULTS Sixty-nine patients (44%) were diagnosed with ≥pT3 disease on RC specimens. HE-LVI was detected in 38 (24%) patients while IHC-LVI in 57 (36%). Twenty-six (46%) of the 57 patients with positive IHC-LVI was determined negative for HE-LVI, while 7 (18%) of the 38 patients with positive HE-LVI was determined negative by IHC. In univariate analyses, clinical T (cT) stage, tumor multifocality, hydronephrosis, and HE-LVI were significantly associated with ≥pT3 disease, but v and ly by both HE and IHC staining and IHC-LVI were not. In multivariate analyses, cT stage (p<0.001), hydronephrosis (p=0.002), and HE-LVI (p=0.025) were significant factors for the prediction of ≥pT3 disease. We developed a nomogram using these variables (Figure) and the area under the curve was 0.79. CONCLUSIONS cT stage, hydronephrosis, and HE-LVI were significant preoperative predictors for ≥pT3 disease at RC. Although IHC could detect more LVI in TURBT samples, it failed to be an independent factor in this setting. Additionally, detailed distinction between v and ly invasion status added no clinical value. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e842 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tatsuo Gondo More articles by this author Jun Nakashima More articles by this author Rie Inoue More articles by this author Takeshi Hashimoto More articles by this author Yoshio Ohno More articles by this author Makoto Ohori More articles by this author Toshitaka Nagao More articles by this author Masaaki Tachibana More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2026395409 created "2016-06-24" @default.
• W2026395409 creator A5000514114 @default.
• W2026395409 creator A5011515442 @default.
• W2026395409 creator A5020199498 @default.
• W2026395409 creator A5064917014 @default.
• W2026395409 creator A5069141919 @default.
• W2026395409 creator A5071012389 @default.
• W2026395409 creator A5071174564 @default.
• W2026395409 creator A5078631198 @default.
• W2026395409 date "2015-04-01" @default.
• W2026395409 modified "2023-09-25" @default.
• W2026395409 title "PD41-06 CLINICAL VALUE OF IMMUNOHISTOCHEMICALLY DETECTED LYMPHOVASCULAR INVASION IN TRANSURETHRAL BLADDER TUMOR RESECTION SPECIMEN FOR BLADDER CANCER STAGING BEFORE RADICAL CYSTECTOMY" @default.
• W2026395409 doi "https://doi.org/10.1016/j.juro.2015.02.2414" @default.
• W2026395409 hasPublicationYear "2015" @default.
• W2026395409 type Work @default.
• W2026395409 sameAs 2026395409 @default.
• W2026395409 citedByCount "0" @default.
• W2026395409 crossrefType "journal-article" @default.
• W2026395409 hasAuthorship W2026395409A5000514114 @default.
• W2026395409 hasAuthorship W2026395409A5011515442 @default.
• W2026395409 hasAuthorship W2026395409A5020199498 @default.
• W2026395409 hasAuthorship W2026395409A5064917014 @default.
• W2026395409 hasAuthorship W2026395409A5069141919 @default.
• W2026395409 hasAuthorship W2026395409A5071012389 @default.
• W2026395409 hasAuthorship W2026395409A5071174564 @default.
• W2026395409 hasAuthorship W2026395409A5078631198 @default.
• W2026395409 hasConcept C121608353 @default.
• W2026395409 hasConcept C126322002 @default.
• W2026395409 hasConcept C126894567 @default.
• W2026395409 hasConcept C142724271 @default.
• W2026395409 hasConcept C2775910329 @default.
• W2026395409 hasConcept C2778740770 @default.
• W2026395409 hasConcept C2779013556 @default.
• W2026395409 hasConcept C2780352672 @default.
• W2026395409 hasConcept C2910508445 @default.
• W2026395409 hasConcept C71924100 @default.
• W2026395409 hasConceptScore W2026395409C121608353 @default.
• W2026395409 hasConceptScore W2026395409C126322002 @default.
• W2026395409 hasConceptScore W2026395409C126894567 @default.
• W2026395409 hasConceptScore W2026395409C142724271 @default.
• W2026395409 hasConceptScore W2026395409C2775910329 @default.
• W2026395409 hasConceptScore W2026395409C2778740770 @default.
• W2026395409 hasConceptScore W2026395409C2779013556 @default.
• W2026395409 hasConceptScore W2026395409C2780352672 @default.
• W2026395409 hasConceptScore W2026395409C2910508445 @default.
• W2026395409 hasConceptScore W2026395409C71924100 @default.
• W2026395409 hasIssue "4S" @default.
• W2026395409 hasLocation W20263954091 @default.
• W2026395409 hasOpenAccess W2026395409 @default.
• W2026395409 hasPrimaryLocation W20263954091 @default.
• W2026395409 hasRelatedWork W1986274506 @default.
• W2026395409 hasRelatedWork W2004878460 @default.
• W2026395409 hasRelatedWork W2137361634 @default.
• W2026395409 hasRelatedWork W2348229978 @default.
• W2026395409 hasRelatedWork W2357220635 @default.
• W2026395409 hasRelatedWork W2357375221 @default.
• W2026395409 hasRelatedWork W2373872671 @default.
• W2026395409 hasRelatedWork W2626351964 @default.
• W2026395409 hasRelatedWork W2769229498 @default.
• W2026395409 hasRelatedWork W2791815030 @default.
• W2026395409 hasVolume "193" @default.
• W2026395409 isParatext "false" @default.
• W2026395409 isRetracted "false" @default.
• W2026395409 magId "2026395409" @default.
• W2026395409 workType "article" @default.