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• W2026414056 startingPage "362" @default.
• W2026414056 abstract "1 alpha,25-Dihydroxyvitamin D3 (10(-12) M to 10(-8) M) caused a dose dependent increase in PKC activity in the solubilized membrane fractions of cultured human keratinocytes and in the cytosolic fractions of cultured human fibroblasts. Maximum activity was induced by 1 alpha,25-dihydroxyvitamin D3 at 24 h. Sphingosine, which is believed to inhibit PKC mediated biological responses, blunted 1 alpha,25(OH)2D3's inducement of PKC activity in both keratinocytes and fibroblasts. Identical hormone treatment of vitamin D receptor deficient fibroblasts did not increase PKC activity. Treatment of keratinocytes and fibroblasts with 1 beta,25-dihydroxyvitamin D3, which is believed to be ineffective in inducing genomic responses, did not induce PKC activity." @default.
• W2026414056 created "2016-06-24" @default.
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• W2026414056 date "1995-02-01" @default.
• W2026414056 modified "2023-09-24" @default.
• W2026414056 title "Increased PKC activity in cultured human keratinocytes and fibroblasts after treatment with 1α,25-dihydroxyvitamin D3" @default.
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• W2026414056 doi "https://doi.org/10.1002/jcb.240570220" @default.
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• W2026414056 hasPublicationYear "1995" @default.
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