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- W2026420723 abstract "Abstract Primary cultures of monkey kidney were infected with type 2 adenovirus. The formation of infective virus was first detected at approximately 21 hours after infection. Final yields of 10–50 plaque forming units per cell were obtained at approximately 50 hours. The rate of DNA synthesis, as measured by the rate of incorporation of H3-thymidine into DNA, did not change after infection. The rates of incorporation of H3-uridine into RNA, and of H3-leucine into protein, however, were markedly inhibited in infected cells before infective virus appeared. A striking decrease in the activity of the DNA-dependent RNA polymerase also occurred before virus maturation began. The effects of type 2 adenovirus infection of monkey kidney cells on the activities of deoxythymidine kinase, DNA polymerase, deoxycytidylate deaminase, and aspartate transcarbamylase were investigated. The deoxythymidine kinase activity began to increase at approximately 20 hours after infection, and at 50 hours the activity was four- to sixfold higher than that of the uninfected cells. At 40–60 hours, the deoxycytidylate deaminase and aspartate transcarbamylase activities were slightly but consistently greater than those of control cells by a factor of 1.6–2. The DNA polymerase activity was not changed. The increase in the deoxythymidine kinase activity induced after infection depended on de novo protein synthesis. The induced deoxythymidine kinase activity of the infected cells was more sensitive to feedback inhibition by dTDP, and dTTP, than the enzyme activity of the control cells." @default.
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- W2026420723 date "1966-04-01" @default.
- W2026420723 modified "2023-09-24" @default.
- W2026420723 title "Changes in metabolic and enzymatic activities of monkey kidney cells after infection with adenovirus 2" @default.
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- W2026420723 doi "https://doi.org/10.1016/0042-6822(66)90252-2" @default.
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