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• W2026433986 abstract "The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations." @default.
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• W2026433986 date "2006-07-28" @default.
• W2026433986 modified "2023-10-14" @default.
• W2026433986 title "Circadian Rhythmicity by Autocatalysis" @default.
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• W2026433986 doi "https://doi.org/10.1371/journal.pcbi.0020096" @default.
• W2026433986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1523307" @default.
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