FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026434578> ?p ?o ?g. }

• W2026434578 endingPage "193" @default.
• W2026434578 startingPage "185" @default.
• W2026434578 abstract "Voltage-gated Ca2+ channels select Ca2+ over competing, more abundant ions by means of a high affinity binding site in the pore. The maximum off rate from this site is ∼1,000× slower than observed Ca2+ current. Various theories that explain how high Ca2+ current can pass through such a sticky pore all assume that flux occurs from a condition in which the pore's affinity for Ca2+ transiently decreases because of ion interactions. Here, we use rate theory calculations to demonstrate a different mechanism that requires no transient changes in affinity to quantitatively reproduce observed Ca2+ channel behavior. The model pore has a single high affinity Ca2+ binding site flanked by a low affinity site on either side; ions permeate in single file without repulsive interactions. The low affinity sites provide steps of potential energy that speed the exit of a Ca2+ ion off the selectivity site, just as potential energy steps accelerate other chemical reactions. The steps could be provided by weak binding in the nonselective vestibules that appear to be a general feature of ion channels, by specific protein structures in a long pore, or by stepwise rehydration of a permeating ion. The previous ion-interaction models and this stepwise permeation model demonstrate two general mechanisms, which might well work together, to simultaneously generate high flux and high selectivity in single file pores." @default.
• W2026434578 created "2016-06-24" @default.
• W2026434578 creator A5006500371 @default.
• W2026434578 creator A5031624167 @default.
• W2026434578 date "1998-02-01" @default.
• W2026434578 modified "2023-10-15" @default.
• W2026434578 title "Ion Channel Selectivity through Stepwise Changes in Binding Affinity" @default.
• W2026434578 cites W1547023654 @default.
• W2026434578 cites W1560096041 @default.
• W2026434578 cites W1579561147 @default.
• W2026434578 cites W1987061751 @default.
• W2026434578 cites W1990154764 @default.
• W2026434578 cites W1996629542 @default.
• W2026434578 cites W2005849592 @default.
• W2026434578 cites W2008081245 @default.
• W2026434578 cites W2010168558 @default.
• W2026434578 cites W2014671743 @default.
• W2026434578 cites W2025332945 @default.
• W2026434578 cites W2035658391 @default.
• W2026434578 cites W2042152248 @default.
• W2026434578 cites W2055385895 @default.
• W2026434578 cites W2061225022 @default.
• W2026434578 cites W2066696082 @default.
• W2026434578 cites W2067995523 @default.
• W2026434578 cites W2077049068 @default.
• W2026434578 cites W2092578555 @default.
• W2026434578 cites W2095494064 @default.
• W2026434578 cites W2097813999 @default.
• W2026434578 cites W2099975374 @default.
• W2026434578 cites W2109222629 @default.
• W2026434578 cites W2133464980 @default.
• W2026434578 cites W2145205119 @default.
• W2026434578 cites W2148216946 @default.
• W2026434578 cites W2149452491 @default.
• W2026434578 cites W2159864873 @default.
• W2026434578 cites W2167039845 @default.
• W2026434578 cites W2169981344 @default.
• W2026434578 cites W2170271247 @default.
• W2026434578 cites W2409677353 @default.
• W2026434578 cites W2412344281 @default.
• W2026434578 doi "https://doi.org/10.1085/jgp.111.2.185" @default.
• W2026434578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2222772" @default.
• W2026434578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9450938" @default.
• W2026434578 hasPublicationYear "1998" @default.
• W2026434578 type Work @default.
• W2026434578 sameAs 2026434578 @default.
• W2026434578 citedByCount "99" @default.
• W2026434578 countsByYear W20264345782012 @default.
• W2026434578 countsByYear W20264345782013 @default.
• W2026434578 countsByYear W20264345782014 @default.
• W2026434578 countsByYear W20264345782015 @default.
• W2026434578 countsByYear W20264345782017 @default.
• W2026434578 countsByYear W20264345782019 @default.
• W2026434578 countsByYear W20264345782020 @default.
• W2026434578 countsByYear W20264345782021 @default.
• W2026434578 countsByYear W20264345782022 @default.
• W2026434578 countsByYear W20264345782023 @default.
• W2026434578 crossrefType "journal-article" @default.
• W2026434578 hasAuthorship W2026434578A5006500371 @default.
• W2026434578 hasAuthorship W2026434578A5031624167 @default.
• W2026434578 hasBestOaLocation W20264345781 @default.
• W2026434578 hasConcept C107824862 @default.
• W2026434578 hasConcept C118792377 @default.
• W2026434578 hasConcept C12554922 @default.
• W2026434578 hasConcept C145148216 @default.
• W2026434578 hasConcept C159467904 @default.
• W2026434578 hasConcept C161790260 @default.
• W2026434578 hasConcept C170493617 @default.
• W2026434578 hasConcept C178790620 @default.
• W2026434578 hasConcept C185592680 @default.
• W2026434578 hasConcept C50254741 @default.
• W2026434578 hasConcept C55493867 @default.
• W2026434578 hasConcept C68709404 @default.
• W2026434578 hasConcept C86803240 @default.
• W2026434578 hasConceptScore W2026434578C107824862 @default.
• W2026434578 hasConceptScore W2026434578C118792377 @default.
• W2026434578 hasConceptScore W2026434578C12554922 @default.
• W2026434578 hasConceptScore W2026434578C145148216 @default.
• W2026434578 hasConceptScore W2026434578C159467904 @default.
• W2026434578 hasConceptScore W2026434578C161790260 @default.
• W2026434578 hasConceptScore W2026434578C170493617 @default.
• W2026434578 hasConceptScore W2026434578C178790620 @default.
• W2026434578 hasConceptScore W2026434578C185592680 @default.
• W2026434578 hasConceptScore W2026434578C50254741 @default.
• W2026434578 hasConceptScore W2026434578C55493867 @default.
• W2026434578 hasConceptScore W2026434578C68709404 @default.
• W2026434578 hasConceptScore W2026434578C86803240 @default.
• W2026434578 hasIssue "2" @default.
• W2026434578 hasLocation W20264345781 @default.
• W2026434578 hasLocation W20264345782 @default.
• W2026434578 hasLocation W20264345783 @default.
• W2026434578 hasLocation W20264345784 @default.
• W2026434578 hasOpenAccess W2026434578 @default.
• W2026434578 hasPrimaryLocation W20264345781 @default.
• W2026434578 hasRelatedWork W1995644121 @default.
• W2026434578 hasRelatedWork W2006471881 @default.
• W2026434578 hasRelatedWork W2008590342 @default.
• W2026434578 hasRelatedWork W2036143465 @default.

• next