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• W2026437739 endingPage "18" @default.
• W2026437739 startingPage "10" @default.
• W2026437739 abstract "The pathogenesis of diabetic retinopathy is complex, reflecting the array of systemic and tissue-specific metabolic abnormalities. A range of pathogenic pathways are directly linked to hyperglycaemia and dyslipidaemia, and the retina appears to be exquisitely sensitive to damage. Establishing the biochemical and molecular basis for this pathology remains an important research focus. This review concentrates on the formation of a range of protein adducts that form after exposure to modifying intermediates known to be elevated during diabetes. These so-called advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) are thought to play an important role in the initiation and progression of diabetic retinopathy, and mechanisms leading to dysfunction and death of various retinal cells are becoming understood. Perspective is provided on AGE/ALE formation in the retina and the impact that such adducts have on retinal cell function. There will be emphasis placed on the role of the receptor for AGEs and how this may modulate retinal pathology, especially in relation to oxidative stress and inflammation. The review will conclude by discussion of strategies to inhibit AGE/ALE formation or harmful receptor interactions in order to prevent disease progression from the point of diabetes diagnosis to sight-threatening proliferative diabetic retinopathy and diabetic macular oedema." @default.
• W2026437739 created "2016-06-24" @default.
• W2026437739 creator A5016325390 @default.
• W2026437739 creator A5025321891 @default.
• W2026437739 date "2011-06-01" @default.
• W2026437739 modified "2023-10-01" @default.
• W2026437739 title "Diabetes-related adduct formation and retinopathy" @default.
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• W2026437739 doi "https://doi.org/10.1007/s12177-011-9070-x" @default.
• W2026437739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3342411" @default.
• W2026437739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23272270" @default.

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