Matches in SemOpenAlex for { <https://semopenalex.org/work/W2026454163> ?p ?o ?g. }
- W2026454163 endingPage "274" @default.
- W2026454163 startingPage "269" @default.
- W2026454163 abstract "To test the hypothesis that there is lower prevalence of islet antibodies in subjects with newly diagnosed Type 1 diabetes mellitus in young adulthood than in children is associated with less severe diabetes at time of diagnosis.This investigation was based on a nationwide study (Diabetes Incidence Study in Sweden) of 15-34-year-old newly diagnosed diabetic subjects. During 1992-1993, all diabetic subjects (excluding secondary and gestational diabetes) were reported on standardized forms, with information about clinical characteristics at diagnosis. The study examined islet cell antibodies (ICA) by indirect immunofluorescence, and autoantibodies to glutamic acid decarboxylase (GADA), tyrosine phosphatase-like antigen (IA-2A) and insulin (IAA) as well as C-peptide by radioimmunoassay.Blood samples were available from 78 patients with diabetic ketoacidosis (DKA) and 517 non-acidotic patients. The prevalence of ICA (63% vs. 57%), GADA (63% vs. 66%), IA-2A (35% vs. 44%) and IAA (20% vs. 15%) were very similar in patients with or without DKA. The median levels of the four autoantibodies did not differ between the two groups. High blood glucose (P < 0.001) and low C-peptide levels (P < 0.001) were the only parameters found to be related to DKA.The similarities in findings of newly diagnosed diabetic patients with or without DKA regarding ICA, GADA, IA-2A and IAA suggest that there is no relationship between the expression of antigenicity and the severity of beta-cell dysfunction. The lower prevalence of the four autoantibodies in 15-34-year-old diabetic subjects compared with previous findings in children is not explained by misclassification of diabetes type." @default.
- W2026454163 created "2016-06-24" @default.
- W2026454163 creator A5000530609 @default.
- W2026454163 creator A5005436471 @default.
- W2026454163 creator A5006680848 @default.
- W2026454163 creator A5008841181 @default.
- W2026454163 creator A5013030521 @default.
- W2026454163 creator A5018098823 @default.
- W2026454163 creator A5037314810 @default.
- W2026454163 creator A5044288681 @default.
- W2026454163 creator A5044448429 @default.
- W2026454163 creator A5048776421 @default.
- W2026454163 creator A5051898408 @default.
- W2026454163 creator A5052201999 @default.
- W2026454163 creator A5059661783 @default.
- W2026454163 creator A5064869144 @default.
- W2026454163 creator A5078013986 @default.
- W2026454163 date "2000-04-01" @default.
- W2026454163 modified "2023-10-10" @default.
- W2026454163 title "Ketoacidosis in young adults is not related to the islet antibodies at the diagnosis of Type 1 diabetes mellitus – a nationwide study" @default.
- W2026454163 cites W1971239948 @default.
- W2026454163 cites W1972164860 @default.
- W2026454163 cites W1981378658 @default.
- W2026454163 cites W1994824720 @default.
- W2026454163 cites W2002305096 @default.
- W2026454163 cites W2002668738 @default.
- W2026454163 cites W2007884204 @default.
- W2026454163 cites W2009239890 @default.
- W2026454163 cites W2016470327 @default.
- W2026454163 cites W2018217678 @default.
- W2026454163 cites W2019661234 @default.
- W2026454163 cites W2032747194 @default.
- W2026454163 cites W2033607283 @default.
- W2026454163 cites W2041955660 @default.
- W2026454163 cites W2049961697 @default.
- W2026454163 cites W2054637947 @default.
- W2026454163 cites W2059144476 @default.
- W2026454163 cites W2060885760 @default.
- W2026454163 cites W2061658273 @default.
- W2026454163 cites W2069846186 @default.
- W2026454163 cites W2070869321 @default.
- W2026454163 cites W2070972996 @default.
- W2026454163 cites W2071472322 @default.
- W2026454163 cites W2074737418 @default.
- W2026454163 cites W2081636491 @default.
- W2026454163 cites W2082509638 @default.
- W2026454163 cites W2093212346 @default.
- W2026454163 cites W2104258246 @default.
- W2026454163 cites W2108192678 @default.
- W2026454163 cites W2111625815 @default.
- W2026454163 cites W2126437867 @default.
- W2026454163 cites W2141659981 @default.
- W2026454163 cites W2143450422 @default.
- W2026454163 cites W2151688741 @default.
- W2026454163 cites W2151931931 @default.
- W2026454163 cites W2152914276 @default.
- W2026454163 cites W2168112867 @default.
- W2026454163 cites W4238849605 @default.
- W2026454163 cites W4240391045 @default.
- W2026454163 cites W4246172021 @default.
- W2026454163 cites W4252289357 @default.
- W2026454163 doi "https://doi.org/10.1046/j.1464-5491.2000.00265.x" @default.
- W2026454163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10821292" @default.
- W2026454163 hasPublicationYear "2000" @default.
- W2026454163 type Work @default.
- W2026454163 sameAs 2026454163 @default.
- W2026454163 citedByCount "17" @default.
- W2026454163 countsByYear W20264541632012 @default.
- W2026454163 countsByYear W20264541632015 @default.
- W2026454163 countsByYear W20264541632016 @default.
- W2026454163 countsByYear W20264541632019 @default.
- W2026454163 countsByYear W20264541632022 @default.
- W2026454163 crossrefType "journal-article" @default.
- W2026454163 hasAuthorship W2026454163A5000530609 @default.
- W2026454163 hasAuthorship W2026454163A5005436471 @default.
- W2026454163 hasAuthorship W2026454163A5006680848 @default.
- W2026454163 hasAuthorship W2026454163A5008841181 @default.
- W2026454163 hasAuthorship W2026454163A5013030521 @default.
- W2026454163 hasAuthorship W2026454163A5018098823 @default.
- W2026454163 hasAuthorship W2026454163A5037314810 @default.
- W2026454163 hasAuthorship W2026454163A5044288681 @default.
- W2026454163 hasAuthorship W2026454163A5044448429 @default.
- W2026454163 hasAuthorship W2026454163A5048776421 @default.
- W2026454163 hasAuthorship W2026454163A5051898408 @default.
- W2026454163 hasAuthorship W2026454163A5052201999 @default.
- W2026454163 hasAuthorship W2026454163A5059661783 @default.
- W2026454163 hasAuthorship W2026454163A5064869144 @default.
- W2026454163 hasAuthorship W2026454163A5078013986 @default.
- W2026454163 hasConcept C120665830 @default.
- W2026454163 hasConcept C121332964 @default.
- W2026454163 hasConcept C126322002 @default.
- W2026454163 hasConcept C134018914 @default.
- W2026454163 hasConcept C159654299 @default.
- W2026454163 hasConcept C163764329 @default.
- W2026454163 hasConcept C165220095 @default.
- W2026454163 hasConcept C203014093 @default.
- W2026454163 hasConcept C2775849729 @default.
- W2026454163 hasConcept C2778875212 @default.