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- W2026456841 abstract "Endogenous high-affinity Ca2+ buffering and its roles were investigated in mouse cerebellar Purkinje cells with the use of a low-affinity Ca2+ indicator and a high-affinity caged Ca2+ compound. Increases in the cytosolic Ca2+ concentration ([Ca2+]i) were markedly facilitated during repetitive depolarization, resulting in the generation of steep micromolar Ca2+ gradients along dendrites. Such supralinear Ca2+ responses were attributed to the saturation of a large concentration (0.36 mM) of a mobile, high-affinity (dissociation constant, 0.37 μM) Ca2+ buffer with cooperative Ca2+ binding sites, resembling calbindin-D28K, and to an immobile, low-affinity Ca2+ buffer. These data suggest that the high-affinity Ca2+ buffer operates as the neuronal computational element that enables efficient coincidence detection of the Ca2+ signal and that facilitates spatiotemporal integration of the Ca2+ signal at submicromolar [Ca2+]i." @default.
- W2026456841 created "2016-06-24" @default.
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- W2026456841 date "1999-12-01" @default.
- W2026456841 modified "2023-10-14" @default.
- W2026456841 title "Supralinear Ca2+ Signaling by Cooperative and Mobile Ca2+ Buffering in Purkinje Neurons" @default.
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- W2026456841 doi "https://doi.org/10.1016/s0896-6273(00)81045-4" @default.
- W2026456841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10624961" @default.
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